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NCT02794883 · ClinicalTrials.gov registry record · Phase 2
Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma
A Phase 2 study of Recurrent Glioblastoma and Malignant Glioma, sponsored by Northwestern University.
- Completed
- Registry status
- Phase 2
- Development phase
- 36
- Enrollment target
- 1
- Study location
NCT02794883 is a Phase 2 study of Recurrent Glioblastoma and Malignant Glioma that has completed, run by Northwestern University. The registered enrollment target is 36 participants, below the 68-participant average among 62 other Recurrent Glioblastoma trials with a reported enrollment target (47% lower). The trial reports 1 study location across 1 state.
The verdict
NCT02794883, a Phase 2 study of Recurrent Glioblastoma and Malignant Glioma, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
The main purpose of this trial is to investigate the effects of a new class of drugs that help the patient's immune system attack their tumor (glioblastoma multiforme - GBM). These drugs have already shown benefit in some other cancer types and are now being explored in GBM. Both tremelimumab and durvalumab (MEDI4736) are "investigational" drugs, which means that the drugs are not approved by the Food and Drug Administration (FDA). Both drugs are antibodies (proteins used by the immune system to fight infections and cancers). Durvalumab attaches to a protein in tumors called PD-L1. It may prevent cancer growth by helping certain blood cells of the immune system get rid of the tumor. Tremelimumab stimulates (wakes up) the immune system to attack the tumor by inhibiting a protein molecule called CTLA-4 on immune cells. Combining the actions of these drugs may result in better treatment options for patients with glioblastoma.
Conditions Studied
Interventions
- BIOLOGICAL Durvalumab
- OTHER Laboratory Biomarker Analysis
- PROCEDURE Surgical Procedure
- BIOLOGICAL Tremelimumab
Study Locations (1)
Illinois
- Northwestern University - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2016-11-01 |
| Est. Completion | 2020-06-17 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02794883
The ClinicalTrials.gov registry entry for NCT02794883 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 68-participant average among 62 other Recurrent Glioblastoma trials with a reported enrollment target (47% lower). The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Recurrent Glioblastoma appearing as the primary indexed condition, and to 4 interventions - of which Durvalumab is the first listed.
NCT02794883 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.
Frequently Asked Questions
What is clinical trial NCT02794883 about?
NCT02794883 is a clinical study titled "Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma". The main purpose of this trial is to investigate the effects of a new class of drugs that help the patient's immune system attack their tumor (glioblastoma multiforme - GBM). These drugs have already shown benefit in some other cancer types and are now being explored in GBM. Both tremelimumab and du...
What is the current status of trial NCT02794883?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 36 participants. The study started on 2016-11-01. Estimated completion is 2020-06-17.
What conditions does trial NCT02794883 study?
This clinical trial studies the following conditions: Recurrent Glioblastoma, Malignant Glioma.
What interventions are being tested in trial NCT02794883?
The interventions under investigation include: Durvalumab (BIOLOGICAL), Laboratory Biomarker Analysis (OTHER), Surgical Procedure (PROCEDURE), Tremelimumab (BIOLOGICAL).
Who is sponsoring clinical trial NCT02794883?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02794883 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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