Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 16 recruiting now official registry

Insulin Sensitivity clinical trials

Every US clinical trial registered for Insulin Sensitivity — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

30 US clinical trials · 16 currently recruiting

The research picture

Insulin Sensitivity has 30 registered US clinical trials, 16 of them open to new participants right now — about 53% of the total.

16
recruiting participants now
53%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Pennington Biomedical Research Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 150 participants

The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)

Arkansas Children's Hospital Research Institute

NCT05992688

RECRUITING 90 participants

Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

University of Colorado, Denver

NCT04596592

RECRUITING NA 77 participants

Mechanisms of Ultrasound Neuromodulation Effects in Diabetes

Yale University

NCT06042517

RECRUITING NA 70 participants

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

University of Colorado, Denver

NCT06129110

RECRUITING NA 70 participants

Effect of Sleep Extension on Ceramides in People with Overweight and Obesity

University of Utah

NCT06180837

RECRUITING NA 68 participants

Metabolic Adaptations to Weight Loss With and Without Exercise

University of Michigan

NCT05806801

RECRUITING Phase 1 60 participants

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

Kalie Tommerdahl

NCT05065372

RECRUITING NA 55 participants

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

Stanford University

NCT05833217

RECRUITING NA 50 participants

Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers

Colorado State University

NCT06550115

RECRUITING NA 32 participants

Countermeasures to Circadian Misalignment

Colorado State University

NCT04966351

RECRUITING NA 30 participants

Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes

Virginia Polytechnic Institute and State University

NCT05441982

RECRUITING NA 30 participants

Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

Virginia Polytechnic Institute and State University

NCT05337098

RECRUITING NA 20 participants

Circadian Intervention to Improve Cardiometabolic Health

University of Utah

NCT05943626

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

RECRUITING NA 12 participants

Effect of Pulsatile Hormone Administration on Insulin Action

Pennington Biomedical Research Center

NCT06216665

RECRUITING NA 8 participants

Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition

Pennington Biomedical Research Center

NCT07265323

ACTIVE NOT RECRUITING NA 103 participants

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT04267705

ACTIVE NOT RECRUITING NA 75 participants

Impact of Sleep Extension in Adolescents

University of Colorado, Denver

NCT03500458

ACTIVE NOT RECRUITING NA 66 participants

Understanding Dose Related Effects of Strawberry

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06173765

COMPLETED NA 604 participants

Metabolic Health Improvement Program: Effects of a Workplace Sugary Beverages Sales Ban and Motivational Counseling

University of California, San Francis

NCT05972109

COMPLETED NA 166 participants

Mediterranean Style Diet and Low Glycemic Responses

Purdue University

NCT03410719

COMPLETED Phase 2 69 participants

Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)

The University of Texas Health Science Center at San Antonio

NCT02127125

COMPLETED 48 participants

Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity

Pennington Biomedical Research Center

NCT00936130

COMPLETED NA 41 participants

A Randomized, Crossover Study to Assess the Effects of Dietary Fiber-containing Bars on Glucose and Insulin Responses

Midwest Center for Metabolic and Cardiovascular Research

NCT03796286

COMPLETED 35 participants

Mitochondrial Function in Circulating Cells and Muscle Tissue

University of Arkansas

NCT02700698

COMPLETED NA 24 participants

Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety

Midwest Center for Metabolic and Cardiovascular Research

NCT03689738

COMPLETED 15 participants

Effects of Regular Activity on Physiology Between Recreational Athletes of Different Body Fatness

Florida State University

NCT05154422

COMPLETED 13 participants

Development of a Novel Method to Measure Insulin Sensitivity in Humans: A Pilot Study

Pennington Biomedical Research Center

NCT04774081

COMPLETED Early Phase 1 9 participants

Low Dose Fat-Induced Insulin Resistance

University of Pennsylvania

NCT03479671

COMPLETED Early Phase 1 4 participants

Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM

The University of Texas Health Science Center at San Antonio

NCT05093517

Reading the Insulin Sensitivity Trial Landscape

ClinicalTrials.gov lists 30 US studies indexed under Insulin Sensitivity, and 16 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Insulin Sensitivity shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Insulin Sensitivity is led by Pennington Biomedical Research Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 30 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Insulin Sensitivity?

PlainTrial tracks 30 US clinical trials for Insulin Sensitivity, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Insulin Sensitivity?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →