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NCT05441982 · ClinicalTrials.gov registry record · NA
Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes
A NA study of Insulin Sensitivity and Inflammatory Markers, sponsored by Virginia Polytechnic Institute and State University.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT05441982: Recruiting NA study of Insulin Sensitivity and Inflammatory Markers, sponsored by Virginia Polytechnic Institute and State University.
NCT05441982 is a NA study of Insulin Sensitivity and Inflammatory Markers that is actively recruiting participants, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 30 participants, below the 72-participant average among 29 other Insulin Sensitivity trials with a reported enrollment target (58% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05441982, a NA study of Insulin Sensitivity and Inflammatory Markers, is actively recruiting participants, sponsored by Virginia Polytechnic Institute and State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of saccharin, but not acesulfame potassium, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.
Primary Outcome
The area under the curve (AUC) glucose concentrations, mg/dl from the continuous glucose monitoring at baseline and follow-up will be used
Conditions Studied
Interventions
- OTHER Non-Nutritive Sweetener Intake and impact on glucose homeostasis
Study Locations (1)
Virginia
- Virginia Tech - Blacksburg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2023-09-21 |
| Est. Completion | 2026-11-28 |
| Phase | NA |
What NCT05441982 shows while recruiting
NCT05441982 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 72-participant average among 29 other Insulin Sensitivity trials with a reported enrollment target (58% lower).
The record links to 4 conditions, with Insulin Sensitivity appearing as the primary indexed condition, and to 1 intervention - of which Non-Nutritive Sweetener Intake and impact on glucose homeostasis is the first listed.
NCT05441982 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT05441982 about?
NCT05441982 is a clinical study titled "Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes". Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could oc...
What is the current status of trial NCT05441982?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2023-09-21. Estimated completion is 2026-11-28.
What conditions does trial NCT05441982 study?
This clinical trial studies the following conditions: Insulin Sensitivity, Inflammatory Markers, Continuous Glucose Monitoring, Oral Glucose Tolerance.
What interventions are being tested in trial NCT05441982?
The interventions under investigation include: Non-Nutritive Sweetener Intake and impact on glucose homeostasis (OTHER).
Who is sponsoring clinical trial NCT05441982?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05441982 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Insulin Sensitivity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05441982's enrollment target sits among peer trials
30 20th of 29 higher than 9 of 29 other Insulin Sensitivity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Insulin Sensitivity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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