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Hypercholesterolemia clinical trials
5 of 63 indexed Hypercholesterolemia trials are currently recruiting.
63 US clinical trials · 5 currently recruiting
Hypercholesterolemia is the subject of 63 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis, running 4 of these trials.
The research picture
Hypercholesterolemia has 63 registered US clinical trials, 5 of them open to new participants right now, about 8% of the total.
- 5
- recruiting participants now
- 8%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Novartis
Active & Recent Trials
63 total, page 1 of 2
Causes and Natural History of Dyslipidemias
National Heart, Lung, and Blood Institute (NHLBI)
NCT00353782
Church-based Health Intervention to Eliminate Racial Inequalities in Cardiovascular Health
Tulane University
NCT06065098
Pharmacogenomic Informed Statin Prescribing
VA Office of Research and Development
NCT06568601
Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial
Wake Forest University Health Sciences
NCT06488105
Pharmacokinetics of Butyrate Tablet BKR-017
BioKier
NCT06556745
Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension
Merck Sharp & Dohme
NCT06492291
A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
University of Utah
NCT06423365
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
Johns Hopkins University
NCT02694094
Evaluating the Efficacy of Pediatric Lipid Screening Alerts
Geisinger Clinic
NCT04118348
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00000620
Long-term Safety and Tolerability of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY Long Term)
Sanofi
NCT01507831
Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo
Regeneron Pharmaceuticals
NCT02957682
12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe
AstraZeneca
NCT00525824
Actual Use Trial of Atorvastatin Calcium 10 mg
Pfizer's Upjohn has merged with Mylan to form Viatris
NCT01964326
Study of a Holistic Health Program for United Methodist Clergy
Duke Clergy Health Initiative
NCT01564719
Cholesterol and Pharmacogenetic Study
UCSF Benioff Children's Hospital Oakland
NCT00451828
Open Label Study of Long Term Safety Evaluation of Alirocumab
Sanofi
NCT01954394
GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound
Amgen
NCT01813422
Study to Evaluate the Efficacy and Safety of an Every Four Weeks Treatment Regimen of Alirocumab (REGN727/ SAR236553) in Patients With Primary Hypercholesterolemia (ODYSSEY CHOICE 1)
Regeneron Pharmaceuticals
NCT01926782
A Real-world Study to Assess the Characteristics and Long-term Effectiveness of Inclisiran in Chinese Adult Patients
Novartis
NCT06595069
Potential Risk Factors for Stroke
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001368
Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia
Amgen
NCT02739984
Efficacy of Lapaquistat Acetate Alone or Combined With Rosuvastatin in Subjects With Hypercholesterolemia
Takeda
NCT00249912
Efficacy and Safety of Valsartan and the Combination of Valsartan and Simvastatin
Novartis
NCT00385931
A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia
Novartis
NCT00171093
Efficacy and Safety of Inclisiran as Monotherapy in Patients With Primary Hypercholesterolemia Not Receiving Lipid-lowering Therapy.
Novartis Pharmaceuticals
NCT05763875
Evaluation of ETC-1002, Ezetimibe, and the Combination in Hypercholesterolemic Patients
Esperion Therapeutics
NCT01941836
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With High Cardiovascular Risk and Hypercholesterolemia (ODYSSEY COMBO I)
Sanofi
NCT01644175
A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH)
Merck Sharp & Dohme
NCT05952869
A Study to Evaluate the Efficacy and Safety of Enlicitide Decanoate (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018) CORALreef AddOn
Merck Sharp & Dohme
NCT06450366
Metabolic Abnormalities in HIV Infected and Uninfected Young Women
University of North Carolina, Chapel Hill
NCT00067587
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)
Esperion Therapeutics
NCT03001076
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
National Heart, Lung, and Blood Institute (NHLBI)
NCT01212900
Study of Oral MD-0727 Administered to Patients With Primary Hypercholesterolemia
Ironwood Pharmaceuticals
NCT00404001
Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension
Esperion Therapeutics
NCT02178098
A Study Comparing CoQ10 Levels While Taking 3 Different Statins
University of Kansas Medical Center
NCT01660191
A Study To Assess The Safety Of PF-05335810 In Hypercholesterolemic Subjects
Pfizer
NCT01720537
Study to Compare Welchol and TriCor to TriCor Alone in Patients With High Cholesterol
Daiichi Sankyo
NCT00754039
Diets Enriched With Pecans
University of Georgia
NCT04376632
The Effect of BiosLife on Serum Lipids
University of Utah
NCT00457756
Pilot Study To Assess CAT-2003 in Patients With Hyperlipidemia
Catabasis Pharmaceuticals
NCT01912560
Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus
Mayo Clinic
NCT00217061
A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial Hypercholesterolemia
Novartis
NCT06507852
Study of the Response of Human Small Blood Vessels
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001622
Bioequivalence Study Comparing A New 10 Mg Atorvastatin Tablet To A 10 Mg Atorvastatin Commercial Tablet
Pfizer's Upjohn has merged with Mylan to form Viatris
NCT00917579
Safety, Tolerability, PK and PD of LGT209 in Healthy Volunteers and Patients With Hypercholesterolemia
Novartis Pharmaceuticals
NCT01979601
Ascending Multi-dose Study of REGN727(SAR236553) With and Without Concomitant Atorvastatin
Regeneron Pharmaceuticals
NCT01161082
A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Simvastatin for at Least 4 Weeks.
Daiichi Sankyo
NCT00753779
Safety And Tolerability Of Multiple Doses Of PF-04950615 (RN316) In Subjects With Hypercholesterolemia
Pfizer
NCT01243151
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C
Esperion Therapeutics
NCT03051100
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 10 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hypercholesterolemia Trial Landscape
63 indexed Hypercholesterolemia studies · 5 recruiting (8%).
Phase mix: 26 late (III/IV) vs 18 early (I/II).
Top sponsor: Novartis (4 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hypercholesterolemia?
PlainTrial tracks 63 US clinical trials for Hypercholesterolemia, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hypercholesterolemia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.