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COMPLETED Phase 3

Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia

NCT02739984 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the effect of 12 weeks of subcutaneous evolocumab taken monthly compared with subcutaneous placebo taken monthly on low density lipoprotein cholesterol (LDL-C) in adults with type 2 diabetes mellitus and high blood cholesterol on a maximally tolerated oral dose of statin of at least moderate-intensity.

Interventions

  • BIOLOGICAL Evolocumab
  • DRUG Placebo to Evolocumab

Study Locations (20)

Florida

  • Research Site — Boca Raton
  • Research Site — Coral Gables
  • Research Site — Daytona Beach
  • Research Site — Fleming Island
  • Research Site — Hollywood
  • Research Site — Inverness
  • Research Site — Jacksonville
  • Research Site — Miami

California

  • Research Site — Lomita
  • Research Site — Los Angeles
  • Research Site — Roseville
  • Research Site — San Ramon
  • Research Site — Spring Valley
  • Research Site — Tarzana
  • Research Site — Walnut Creek

Colorado

  • Research Site — Denver
  • Research Site — Lakewood

Alabama

  • Research Site — Tuscumbia

Arizona

  • Research Site — Phoenix

Delaware

  • Research Site — Wilmington

Trial Details

FieldValue
Enrollment Target 424 participants
Start Date 2016-05-17
Est. Completion 2017-08-03
Phase Phase 3

Sponsor

Amgen

266 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02739984

The ClinicalTrials.gov registry entry for NCT02739984 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 424 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Type 2 Diabetes appearing as the primary indexed condition, and to 2 interventions — of which Evolocumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02739984 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02739984 about?

NCT02739984 is a clinical study titled "Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia". The purpose of this study is to evaluate the effect of 12 weeks of subcutaneous evolocumab taken monthly compared with subcutaneous placebo taken monthly on low density lipoprotein cholesterol (LDL-C) in adults with type 2 diabetes mellitus and high blood cholesterol on a maximally tolerated oral do...

What is the current status of trial NCT02739984?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 424 participants. The study started on 2016-05-17. Estimated completion is 2017-08-03.

What conditions does trial NCT02739984 study?

This clinical trial studies the following conditions: Type 2 Diabetes, Hypercholesterolemia, Mixed Dyslipidemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02739984?

The interventions under investigation include: Evolocumab (BIOLOGICAL), Placebo to Evolocumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02739984?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02739984 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial