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ClinicalTrials.gov 5 recruiting now official registry

Hypercholesterolemia clinical trials

5 of 63 indexed Hypercholesterolemia trials are currently recruiting.

63 US clinical trials · 5 currently recruiting

Hypercholesterolemia is the subject of 63 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis, running 4 of these trials.

The research picture

Hypercholesterolemia has 63 registered US clinical trials, 5 of them open to new participants right now, about 8% of the total.

5
recruiting participants now
8%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
4
top sponsor: Novartis
Phase 18Phase 210Phase 318Phase 48

Active & Recent Trials

63 total, page 2 of 2

COMPLETED Phase 2 60 participants

The Safety & Efficacy of Combination BMS-201038 (AEGR-733) & Ezetimibe vs. Monotherapy in Moderate Hypercholesterolemia

Aegerion Pharmaceuticals

NCT00405067

COMPLETED NA 60 participants

Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol

The Cleveland Clinic

NCT01817491

COMPLETED Phase 2 58 participants

Open-Label Extension of Study R727-CL-1003 (NCT01266876) to Evaluate the Long-Term Safety and Efficacy of Alirocumab (REGN727) in Participants With Heterozygous Familial Hypercholesterolemia (HeFH)

Regeneron Pharmaceuticals

NCT01576484

COMPLETED NA 57 participants

Effect of Diabetes Mellitus on Cholesterol Metabolism

Medical College of Wisconsin

NCT00879710

COMPLETED Phase 1 43 participants

Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults

University of Missouri-Columbia

NCT01227330

COMPLETED Phase 2 36 participants

Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells

Emory University

NCT00166036

COMPLETED Phase 4 34 participants

Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) Cholesterol

Bronx VA Medical Center

NCT00762164

COMPLETED Phase 2 32 participants

Open-Label Extension to Evaluate the Longer Term Efficacy and Safety of LIB003

LIB Therapeutics

NCT03847974

COMPLETED NA 30 participants

Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00046267

COMPLETED NA 22 participants

Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS

Beth Israel Deaconess Medical Center

NCT01702987

COMPLETED 19 participants

Using Nudges to Implement Comparative Effectiveness

NYU Langone Health

NCT01575171

COMPLETED Phase 1 13 participants

A Study of LY3015014 in Healthy Participants With High Cholesterol

Eli Lilly and Company

NCT01671085

COMPLETED NA 10 participants

Metabolism And Health Effects Of Citrus Limonoids in Hypercholesterolemic Humans

USDA, Western Human Nutrition Research Center

NCT02011789

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Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 10
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hypercholesterolemia Trial Landscape

63 indexed Hypercholesterolemia studies · 5 recruiting (8%).

Phase mix: 26 late (III/IV) vs 18 early (I/II).

Top sponsor: Novartis (4 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hypercholesterolemia?

PlainTrial tracks 63 US clinical trials for Hypercholesterolemia, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hypercholesterolemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.