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NCT02471430 · ClinicalTrials.gov registry record · Phase 1
Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy
A Phase 1 study of HIV Infection, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT02471430: Completed Phase 1 study of HIV Infection, sponsored by Massachusetts General Hospital.
NCT02471430 is a Phase 1 study of HIV Infection that has completed, run by Massachusetts General Hospital. The registered enrollment target is 17 participants, below the 243-participant average among 73 other HIV Infection trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02471430, a Phase 1 study of HIV Infection, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is a prospective, open-label, randomized, three-arm, dose-escalation exploratory pilot clinical trial involving HIV-1 infected participants treated with suppressive combination antiretroviral combination therapy (cART). The study will test whether combined treatment with the histone deacetylase inhibitor panobinostat and the immunomodulatory cytokine Interferon-alpha2a can reduce the residual reservoir of HIV-1 infected cells that persist during treatment with currently available antiretroviral drugs.
Primary Outcome
Cumulative frequency and severity of Grade ≥ 1 adverse events, Grade ≥ 1 lab abnormalities or serious adverse events
Conditions Studied
Interventions
- DRUG Panobinostat
- DRUG Pegylated Interferon-alpha2a
Study Locations (1)
Massachusetts
- Massachusetts General Hospital CRS (MGH CRS) - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2016-05 |
| Est. Completion | 2023-12 |
| Phase | Phase 1 |
What the finished NCT02471430 record still lists
NCT02471430 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 243-participant average among 73 other HIV Infection trials with a reported enrollment target (93% lower).
The record links to 1 condition, with HIV Infection appearing as the primary indexed condition, and to 2 interventions - of which Panobinostat is the first listed.
NCT02471430 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02471430 about?
NCT02471430 is a clinical study titled "Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy". This study is a prospective, open-label, randomized, three-arm, dose-escalation exploratory pilot clinical trial involving HIV-1 infected participants treated with suppressive combination antiretroviral combination therapy (cART). The study will test whether combined treatment with the histone deace...
What is the current status of trial NCT02471430?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 17 participants. The study started on 2016-05. Estimated completion is 2023-12.
What conditions does trial NCT02471430 study?
This clinical trial studies the following conditions: HIV Infection.
What interventions are being tested in trial NCT02471430?
The interventions under investigation include: Panobinostat (DRUG), Pegylated Interferon-alpha2a (DRUG).
Who is sponsoring clinical trial NCT02471430?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02471430 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV Infection
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02471430's enrollment target sits among peer trials
17 66th of 73 higher than 8 of 73 other HIV Infection trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infection trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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