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NCT03431090 · ClinicalTrials.gov registry record · Phase 1
Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia
A Phase 1 study of Hematologic Malignancy and Myelodysplasia, sponsored by Nationwide Children's Hospital.
- Active
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT03431090: Active Phase 1 study of Hematologic Malignancy and Myelodysplasia, sponsored by Nationwide Children's Hospital.
NCT03431090 is a Phase 1 study of Hematologic Malignancy and Myelodysplasia that is active but no longer recruiting, run by Nationwide Children's Hospital. The registered enrollment target is 20 participants, below the 228-participant average among 48 other Hematologic Malignancy trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03431090, a Phase 1 study of Hematologic Malignancy and Myelodysplasia, is active but no longer recruiting, sponsored by Nationwide Children's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a Phase I/II study designed to evaluate the kinetics of hematopoietic reconstitution and the incidence of acute chronic GVHD after partially matched related donor hematopoietic cell transplantation using an αβTCR/CD19+ cell depleted graft.
Primary Outcome
Patients undergoing partially matched related donor hematopoietic cell transplantation with an αβT cell / CD19+ B cell depleted graft should have an improved rate of engraftment.
Conditions Studied
Interventions
- DEVICE CliniMACS® TCRαβ/CD19 Combined Depletion System
Study Locations (1)
Ohio
- Nationwide Children's Hospital - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2018-03-02 |
| Est. Completion | 2026-01 |
| Phase | Phase 1 |
What the registry record for NCT03431090 still lists
NCT03431090 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 228-participant average among 48 other Hematologic Malignancy trials with a reported enrollment target (91% lower).
The record links to 2 conditions, with Hematologic Malignancy appearing as the primary indexed condition, and to 1 intervention - of which CliniMACS® TCRαβ/CD19 Combined Depletion System is the first listed.
NCT03431090 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03431090 about?
NCT03431090 is a clinical study titled "Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia". This is a Phase I/II study designed to evaluate the kinetics of hematopoietic reconstitution and the incidence of acute chronic GVHD after partially matched related donor hematopoietic cell transplantation using an αβTCR/CD19+ cell depleted graft.
What is the current status of trial NCT03431090?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2018-03-02. Estimated completion is 2026-01.
What conditions does trial NCT03431090 study?
This clinical trial studies the following conditions: Hematologic Malignancy, Myelodysplasia.
What interventions are being tested in trial NCT03431090?
The interventions under investigation include: CliniMACS® TCRαβ/CD19 Combined Depletion System (DEVICE).
Who is sponsoring clinical trial NCT03431090?
This trial is sponsored by Nationwide Children's Hospital, which has 188 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03431090 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hematologic Malignancy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03431090's enrollment target sits among peer trials
20 42nd of 48 higher than 4 of 48 other Hematologic Malignancy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hematologic Malignancy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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