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Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity
NCT03890614 · View on ClinicalTrials.gov ↗
Study Summary
The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models. The investigators overarching hypothesis is that 3D organoids are ideal to test chemosensitivity in real time, to provide personalized medicine and guidance in the setting of relapsed hematologic malignancy and potentially other cancers.
Conditions Studied
Interventions
- OTHER Ancillary-Correlative - Creation of three-dimensional myeloma organoids using marrow aspirates
Study Locations (1)
North Carolina
- Wake Forest Baptist Comprehensive Cancer Center — Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2019-05-16 |
| Est. Completion | 2027-02 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03890614
The ClinicalTrials.gov registry entry for NCT03890614 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Wake Forest University Health Sciences, which has 1,061 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Hematologic Malignancy appearing as the primary indexed condition, and to 1 intervention — of which Ancillary-Correlative - Creation of three-dimensional myeloma organoids using marrow aspirates is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03890614 reports 1 study location spanning 1 distinct geographic area — top geographies include North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03890614 about?
NCT03890614 is a clinical study titled "Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity". The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models. The investigators overarching hypothesis is that 3D organoids are ideal to test chemosensitivity in real time, to provide personalized medicine and guidan...
What is the current status of trial NCT03890614?
This trial is currently recruiting. The enrollment target is 70 participants. The study started on 2019-05-16. Estimated completion is 2027-02.
What conditions does trial NCT03890614 study?
This clinical trial studies the following conditions: Hematologic Malignancy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03890614?
The interventions under investigation include: Ancillary-Correlative - Creation of three-dimensional myeloma organoids using marrow aspirates (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03890614?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,061 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03890614 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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