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Heart Transplant clinical trials
Every US clinical trial registered for Heart Transplant — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
13 US clinical trials · 7 currently recruiting
The research picture
Heart Transplant has 13 registered US clinical trials, 7 of them open to new participants right now — about 54% of the total.
- 7
- recruiting participants now
- 54%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 6
- top sponsor: TransMedics
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
US National OCS Heart Perfusion (OHP) Registry
TransMedics
NCT05915299
Enhancing Heart Allograft Function With the OCS Heart System Trial
TransMedics
NCT07145515
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
University of California, San Francis
NCT05933083
Randomized Trial of SGLT2i in Heart Transplant Recipients
VA Office of Research and Development
NCT06625073
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
Masonic Cancer Center, University of Minnesota
NCT05025774
Belatacept in Heart Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06478017
XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)
XVIVO Perfusion
NCT06895070
OCS DCD Heart + CAP Continued Follow-Up
TransMedics
NCT05741723
Expanding the Pool in Orthotopic Heart Transplantation
Mary E. Keebler, MD
NCT03222531
Donors After Circulatory Death Heart Trial
TransMedics
NCT03831048
Development of Non-invasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation
Natera
NCT05309382
Heart EXPAND Continued Access Protocol
TransMedics
NCT03835754
International EXPAND Heart Pivotal Trial
TransMedics
NCT02323321
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Heart Transplant Trial Landscape
ClinicalTrials.gov lists 13 US studies indexed under Heart Transplant, and 7 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Heart Transplant shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Heart Transplant is led by TransMedics with 6 indexed trials, alongside 7 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Heart Transplant?
PlainTrial tracks 13 US clinical trials for Heart Transplant, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Transplant?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.