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ClinicalTrials.gov 8 recruiting now official registry

ACL Injury clinical trials

8 of 13 indexed ACL Injury trials are currently recruiting.

13 US clinical trials · 8 currently recruiting

ACL Injury is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Hospital for Special Surgery, New York, running 2 of these trials.

The research picture

ACL Injury has 13 registered US clinical trials, 8 of them open to new participants right now, about 62% of the total.

8
recruiting participants now
62%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Hospital for Special Surgery, New York
Phase 11Phase 31Phase 41

Active & Recent Trials

13 total, page 1 of 1

RECRUITING 5,000 participants

Baseline ACL Injury Risk Screening and Normative Data

Sanford Health

NCT06635668

RECRUITING NA 240 participants

The Pediatric ALL Evaluation and Trial

Ann & Robert H Lurie Children's Hospital of Chicago

NCT04825587

RECRUITING NA 226 participants

Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery

University Hospitals Cleveland Medical Center

NCT05488054

RECRUITING NA 200 participants

Mindfulness and ACL Surgery

University of Wisconsin, Madison

NCT05542563

RECRUITING Phase 4 40 participants

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Hospital for Special Surgery, New York

NCT06311513

RECRUITING Early Phase 1 30 participants

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Austin V Stone

NCT04572256

RECRUITING NA 30 participants

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

University of Michigan

NCT06529679

RECRUITING NA 9 participants

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

University of Michigan

NCT06529692

ACTIVE NOT RECRUITING NA 105 participants

Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes

Mayo Clinic

NCT05273463

ACTIVE NOT RECRUITING NA 60 participants

BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft

Brooke Army Medical Center

NCT04519801

COMPLETED NA 47 participants

Blood Flow Restriction Training (BFR) in an Adolescent Population

Connecticut Children's Medical Center

NCT04285879

COMPLETED NA 40 participants

Acupuncture ACL (Anterior Cruciate Ligament)

Hospital for Special Surgery, New York

NCT03711734

COMPLETED Phase 3 26 participants

Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound

University of Miami

NCT04993339

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the ACL Injury Trial Landscape

13 indexed ACL Injury studies · 8 recruiting (62%).

Phase mix: 2 late (III/IV) vs 1 early (I/II).

Top sponsor: Hospital for Special Surgery, New York (2 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for ACL Injury?

PlainTrial tracks 13 US clinical trials for ACL Injury, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for ACL Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.