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ACL Injury clinical trials
Every US clinical trial registered for ACL Injury — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
13 US clinical trials · 8 currently recruiting
The research picture
ACL Injury has 13 registered US clinical trials, 8 of them open to new participants right now — about 62% of the total.
- 8
- recruiting participants now
- 62%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Hospital for Special Surgery, New York
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Baseline ACL Injury Risk Screening and Normative Data
Sanford Health
NCT06635668
The Pediatric ALL Evaluation and Trial
Ann & Robert H Lurie Children's Hospital of Chicago
NCT04825587
Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery
University Hospitals Cleveland Medical Center
NCT05488054
Mindfulness and ACL Surgery
University of Wisconsin, Madison
NCT05542563
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
Hospital for Special Surgery, New York
NCT06311513
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
Austin V Stone
NCT04572256
Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction
University of Michigan
NCT06529679
Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
University of Michigan
NCT06529692
Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes
Mayo Clinic
NCT05273463
BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft
Brooke Army Medical Center
NCT04519801
Blood Flow Restriction Training (BFR) in an Adolescent Population
Connecticut Children's Medical Center
NCT04285879
Acupuncture ACL (Anterior Cruciate Ligament)
Hospital for Special Surgery, New York
NCT03711734
Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound
University of Miami
NCT04993339
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the ACL Injury Trial Landscape
ClinicalTrials.gov lists 13 US studies indexed under ACL Injury, and 8 of those are currently open to recruitment — roughly 62% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for ACL Injury shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for ACL Injury is led by Hospital for Special Surgery, New York with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for ACL Injury?
PlainTrial tracks 13 US clinical trials for ACL Injury, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for ACL Injury?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.