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ClinicalTrials.gov 8 recruiting now later-stage tilt small index

ACL Injury: later-stage trial registry

8 of 13 indexed ACL Injury trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #1,315 of 28,707 conditions by registered trial count.

13 US clinical trials · 8 currently recruiting · #1,315 of 28,707 conditions by registered trial count

ACL Injury: 13 US clinical trials tracked, 8 recruiting.

ACL Injury is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Hospital for Special Surgery, New York, running 2 of these trials.

Enrollment posture brief

Registry condition acl-injury

OPEN 8 | RECR 62% | LATE 2 | EARLY 1 | RANK #1315 | SPON 2

Nearest open-share peer: High Risk Myelodysplastic Syndrome (62% recruiting · 13 trials)

ACL Injury (this)62%Acute Biphenotypic Leukemia46.2%Accidental Falls30.8%Acute Decompensated Heart Fa30.8%Actinic Keratoses23.1%
Open-enrollment share among volume-matched conditions near ACL Injury

ACL Injury lists 8 open slots (62% of 13 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for ACL Injury on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. ACL Injury is recruiting above its size-band peers.

    8 of 13 indexed trials (61.5%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates ACL Injury research.

    Hospital for Special Surgery, New York accounts for 2 of 13 trials (15.4%). 11 distinct sponsors appear on at least one study for this condition label.

  3. Most ACL Injury trials plan to enrol fewer than 100 people.

    Median target enrolment is 47 among the 13 trials that report a genuine target (sentinel values excluded). 8 of those (61.5%) plan for fewer than 100 participants.

  4. ACL Injury research is mostly interventional.

    12 interventional and 1 observational studies make up this index (92.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 31Phase 41

Open and recent trials

13 total, page 1 of 1

RECRUITING 5,000 participants

Baseline ACL Injury Risk Screening and Normative Data

Sanford Health

NCT06635668

RECRUITING NA 240 participants

The Pediatric ALL Evaluation and Trial

Ann & Robert H Lurie Children's Hospital of Chicago

NCT04825587

RECRUITING NA 226 participants

Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery

University Hospitals Cleveland Medical Center

NCT05488054

RECRUITING NA 200 participants

Mindfulness and ACL Surgery

University of Wisconsin, Madison

NCT05542563

RECRUITING Phase 4 40 participants

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Hospital for Special Surgery, New York

NCT06311513

RECRUITING Early Phase 1 30 participants

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Austin V Stone

NCT04572256

RECRUITING NA 30 participants

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

University of Michigan

NCT06529679

RECRUITING NA 9 participants

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

University of Michigan

NCT06529692

ACTIVE NOT RECRUITING NA 105 participants

Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes

Mayo Clinic

NCT05273463

ACTIVE NOT RECRUITING NA 60 participants

BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft

Brooke Army Medical Center

NCT04519801

COMPLETED NA 47 participants

Blood Flow Restriction Training (BFR) in an Adolescent Population

Connecticut Children's Medical Center

NCT04285879

COMPLETED NA 40 participants

Acupuncture ACL (Anterior Cruciate Ligament)

Hospital for Special Surgery, New York

NCT03711734

COMPLETED Phase 3 26 participants

Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound

University of Miami

NCT04993339

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 3 1
Phase 4 1

Named interventions

Most-linked intervention names on ACL Injury records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

OOC Drug
1 trials
Acupuncture + Standard of Care Other
1 trials
Classroom-Based Intervention Behavioral
1 trials
Video-Based Intervention Behavioral
1 trials
Standard REHAB Other
1 trials
Blood Flow Restriction (BFR) therapy Other
1 trials
Patients will be randomized into one of two study arms: (1) concomitant ACL and ALL reconstruction or (2) ACL reconstruction alone. Procedure
1 trials
Healthy Minds Program (HMP) App Behavioral
1 trials

US sites by state

Facility locations filed on ACL Injury trials. A trial with sites in several states counts in each.

New York 2 trials
Michigan 2 trials
Wisconsin 1 trials
Texas 1 trials
Ohio 1 trials
North Dakota 1 trials
Kentucky 1 trials
Illinois 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this ACL Injury page

13 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This ACL Injury condition card totals 13 registered trials; most-linked intervention OOC; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.