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Heart Failure With Reduced Ejection Fraction: early-phase trial registry
19 of 28 indexed Heart Failure With Reduced Ejection Fraction trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #577 of 28,707 conditions by registered trial count.
28 US clinical trials · 19 currently recruiting · #577 of 28,707 conditions by registered trial count
Heart Failure With Reduced Ejection Fraction: 28 US clinical trials tracked, 19 recruiting.
Heart Failure With Reduced Ejection Fraction is the subject of 28 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is University of Virginia, running 2 of these trials.
Enrollment posture brief
Registry condition heart-failure-with-reduced-ejection-fraction
OPEN 19 | RECR 68% | LATE 2 | EARLY 4 | RANK #577 | SPON 2
Volume-matched condition peers
Nearest open-share peer: HER2-Negative Breast Cancer (68% recruiting · 50 trials)
Heart Failure With Reduced Ejection Fraction lists 19 open slots (68% of 28 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure With Reduced Ejection Fraction on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure With Reduced Ejection Fraction is recruiting above its size-band peers.
19 of 28 indexed trials (67.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure With Reduced Ejection Fraction trials is spread across many organizations.
University of Virginia accounts for 2 of 28 trials (7.1%). 26 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure With Reduced Ejection Fraction enrolment sits around 178 participants.
Median target enrolment is 178 among the 28 trials that report a genuine target (sentinel values excluded). 12 of those (42.9%) plan for fewer than 100 participants.
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Heart Failure With Reduced Ejection Fraction research is mostly interventional.
21 interventional and 7 observational studies make up this index (75% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
28 total, page 1 of 1
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
Yale University
NCT04237701
Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG
Eko Devices
NCT07087613
Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy
University of Rochester
NCT06543446
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
Massachusetts General Hospital
NCT03480633
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
University of Colorado, Denver
NCT06526988
Left vs Left Randomized Clinical Trial
Baylor College of Medicine
NCT05650658
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Cytokinetics
NCT06736574
Study of JK07 in Patients With Chronic Heart Failure
Salubris Biotherapeutics
NCT06369298
Home-Based Cardiac Rehabilitation for Patients With Heart Failure
Vanderbilt University Medical Center
NCT06479876
Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure
Kansas City Heart Rhythm Research Foundation
NCT06342492
PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction
University of Virginia
NCT05609097
Ketones, SGLT2, HFrEF
The University of Texas Health Science Center at San Antonio
NCT06229678
A Study Investigating the Impact of IMT With CR On Exercise Responses In HF
Mayo Clinic
NCT07086131
The CardioClip Study
Columbia University
NCT06241430
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Johns Hopkins University
NCT06299436
Colchicine in Acutely Decompensated HFREF
University of Virginia
NCT06286423
Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure
YAP Therapeutics
NCT06831825
Pilot Study Lp299v Supplementation in Chronic Heart Failure
Medical College of Wisconsin
NCT05752760
An Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart Failure
InterShunt Technologies
NCT06859970
Assessment of Combined CCM and ICD Device in HFrEF
Impulse Dynamics
NCT05855135
Circulating RNAs in Acute Congestive Heart Failure
Massachusetts General Hospital
NCT03345446
Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
University of Pittsburgh
NCT06576297
Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Novartis
NCT06671314
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Geisinger Clinic
NCT05990296
Hemodynamic-GUIDEd Management of Heart Failure
Abbott Medical Devices
NCT03387813
Virtual Care to Improve Heart Failure Outcomes (VITAL-HF)
Duke University
NCT05602454
A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure
Bristol-Myers Squibb
NCT05952089
EHR Nudges to Improve Quality of Care in HF
Northwestern University
NCT06103565
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure With Reduced Ejection Fraction records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure With Reduced Ejection Fraction trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure With Reduced Ejection Fraction page
28 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 19 Heart Failure With Reduced Ejection Fraction trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Virginia sponsors the most Heart Failure With Reduced Ejection Fraction trials on record, review their full trial history before evaluating a specific study. See University of Virginia's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure With Reduced Ejection Fraction condition card totals 28 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.