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NCT03345446 · ClinicalTrials.gov registry record

Circulating RNAs in Acute Congestive Heart Failure

A clinical trial of Heart Failure With Reduced Ejection Fraction and Heart Failure With Normal Ejection Fraction, sponsored by Massachusetts General Hospital.

Active
Registry status
200
Enrollment target
3
Study locations

NCT03345446 is a study of Heart Failure With Reduced Ejection Fraction and Heart Failure With Normal Ejection Fraction that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 200 participants, below the 3,958-participant average among 27 other Heart Failure With Reduced Ejection Fraction trials with a reported enrollment target (95% lower). The trial reports 3 study locations across 1 state.

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The verdict

NCT03345446, a study of Heart Failure With Reduced Ejection Fraction and Heart Failure With Normal Ejection Fraction, is active but no longer recruiting, sponsored by Massachusetts General Hospital.

ACTIVE NOT RECRUITING
Registry status
200 participants
Enrollment target
3
Study locations

Study Summary

The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo. The investigators are testing the hypothesis that ex-RNA levels change significantly during decongestion therapy and can be used as a marker of those individuals who respond to CHF therapy (in terms of cardiac structure or outcome). Additionally, the translational research design allows the investigators to assay the effects of these RNAs on tissue phenotypes in vitro.

Conditions Studied

Heart Failure With Reduced Ejection Fraction Heart Failure With Normal Ejection Fraction Acute Congestive Heart Failure

Interventions

  • DIAGNOSTIC_TEST Cardiac MRI

Study Locations (3)

Massachusetts

  • Massachusetts General Hospital - Boston
  • Brigham and Women's Hospital - Boston
  • Beth Israel Deaconess Medical Center - Boston

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2016-08-17
Est. Completion 2026-12-31

Sponsor

Massachusetts General Hospital

2,032 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03345446

The ClinicalTrials.gov registry entry for NCT03345446 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,958-participant average among 27 other Heart Failure With Reduced Ejection Fraction trials with a reported enrollment target (95% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Heart Failure With Reduced Ejection Fraction appearing as the primary indexed condition, and to 1 intervention - of which Cardiac MRI is the first listed.

NCT03345446 reports 3 study locations spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT03345446 about?

NCT03345446 is a clinical study titled "Circulating RNAs in Acute Congestive Heart Failure". The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo. The investigators are testing the hypothesis that ex-RNA levels change significantl...

What is the current status of trial NCT03345446?

This trial is currently active not recruiting. The enrollment target is 200 participants. The study started on 2016-08-17. Estimated completion is 2026-12-31.

What conditions does trial NCT03345446 study?

This clinical trial studies the following conditions: Heart Failure With Reduced Ejection Fraction, Heart Failure With Normal Ejection Fraction, Acute Congestive Heart Failure.

What interventions are being tested in trial NCT03345446?

The interventions under investigation include: Cardiac MRI (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT03345446?

This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03345446 being conducted?

This trial has 3 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.