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2026 data Public-data reference. official source

Carcinoma, Hepatocellular

Open-data reference.

28 US clinical trials · 7 currently recruiting

Active & Recent Trials

RECRUITING Phase 4 5,500 participants

National Liver Cancer Screening Trial

University of Texas Southwestern Medical Center

NCT06084234

RECRUITING NA 4,700 participants

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

VA Office of Research and Development

NCT05486572

RECRUITING 200 participants

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)

Travera

NCT05461430

RECRUITING 84 participants

Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma

The University of Texas Health Science Center at San Antonio

NCT03894917

RECRUITING NA 50 participants

90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia

Ochsner Health System

NCT05953961

RECRUITING Phase 1 48 participants

ABX196 in Combination With Nivolumab in Patients With Hepatocellular Carcinoma

Abivax S.A.

NCT03897543

RECRUITING Phase 2 35 participants

Tislelizumab Consolidation After Liver-Directed Therapy for Hepatocellular Carcinoma

Rutgers, The State University of New Jersey

NCT05366829

ACTIVE NOT RECRUITING 766 participants

Case-Control Study of the Glycotest™ HCC Panel Vs AFP for the Detection of Early-stage Hepatocellular Carcinoma

Glycotest

NCT03878550

ACTIVE NOT RECRUITING Phase 3 668 participants

A Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

Hoffmann-La Roche

NCT04102098

ACTIVE NOT RECRUITING Phase 3 480 participants

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Merck Sharp & Dohme

NCT04246177

ACTIVE NOT RECRUITING Phase 1 301 participants

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

Eisai

NCT04008797

ACTIVE NOT RECRUITING Phase 1 48 participants

CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

Carisma Therapeutics

NCT04660929

COMPLETED Phase 3 1,114 participants

Sorafenib as Adjuvant Treatment in the Prevention Of Recurrence of Hepatocellular Carcinoma (STORM)

Bayer

NCT00692770

COMPLETED Phase 3 732 participants

Nexavar-Tarceva Combination Therapy for First Line Treatment of Patients Diagnosed With Hepatocellular Carcinoma

Bayer

NCT00901901

COMPLETED Phase 3 602 participants

A Phase III Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma

Bayer

NCT00105443

COMPLETED Phase 3 558 participants

A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma

Hoffmann-La Roche

NCT03434379

COMPLETED Phase 2 185 participants

A Study of GC33 (RO5137382) in Patients With Advanced or Metastatic Hepatocellular Carcinoma

Hoffmann-La Roche

NCT01507168

COMPLETED Phase 1 89 participants

A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors

Eisai

NCT05091346

COMPLETED Phase 1 83 participants

A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer

Bristol-Myers Squibb

NCT05337137

COMPLETED Phase 1 81 participants

Use of TheraSphere® Yttrium-90 Glass Microspheres for Primary and Metastatic Liver Tumors

Southwestern Regional Medical Center

NCT00493883

COMPLETED 65 participants

Safety and Effectiveness of BioTraceIO Lite for Tissue Damage Assessment Following Liver Tissue Ablation Procedures

Techsomed Medical Technologies

NCT04970212

COMPLETED Phase 1 55 participants

A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

Hoffmann-La Roche

NCT04338685

COMPLETED Phase 1 27 participants

Sorafenib and TRC105 in Hepatocellular Cancer

National Cancer Institute (NCI)

NCT01306058

COMPLETED Phase 2 16 participants

Refametinib(BAY86-9766) in RAS Mutant Hepatocellular Carcinoma (HCC)

Bayer

NCT01915589

COMPLETED NA 14 participants

Advanced Image Guidance Utilized in Liver Surgery

Wake Forest University Health Sciences

NCT01666145

COMPLETED Phase 2 14 participants

Refametinib in Combination With Sorafenib in RAS Mutant Hepatocellular Carcinoma (HCC)

Bayer

NCT01915602

COMPLETED Phase 1 13 participants

Meclizine for Hepatocellular Carcinoma

Tannaz Armaghnay

NCT03253289

COMPLETED Phase 2 11 participants

TRC105 for Liver Cancer That Has Not Responded to Sorafenib

National Cancer Institute (NCI)

NCT01375569

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 5
Phase 3 6
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Carcinoma, Hepatocellular Trial Landscape

ClinicalTrials.gov lists 28 US studies indexed under Carcinoma, Hepatocellular, and 7 of those are currently open to recruitment — roughly 25% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Carcinoma, Hepatocellular shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Carcinoma, Hepatocellular is led by Bayer with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 28 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Carcinoma, Hepatocellular?

PlainTrial tracks 28 US clinical trials for Carcinoma, Hepatocellular, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Carcinoma, Hepatocellular?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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