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NCT06543446 · ClinicalTrials.gov registry record · NA
Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy
A NA study of Heart Failure With Reduced Ejection Fraction, sponsored by University of Rochester.
- Recruiting
- Registry status
- NA
- Development phase
- 3,290
- Enrollment target
- 15
- Study locations
NCT06543446: Recruiting NA study of Heart Failure With Reduced Ejection Fraction, sponsored by University of Rochester.
NCT06543446 is a NA study of Heart Failure With Reduced Ejection Fraction that is actively recruiting participants, run by University of Rochester. The registered enrollment target is 3,290 participants, below the 3,844-participant average among 27 other Heart Failure With Reduced Ejection Fraction trials with a reported enrollment target (14% lower). The trial reports 15 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06543446, a NA study of Heart Failure With Reduced Ejection Fraction, is actively recruiting participants, sponsored by University of Rochester.
- RECRUITING
- Registry status
- NA
- Development phase
- 3,290 participants
- Enrollment target
- 15
- Study locations
Study Summary
The investigators aim to compare the risk of mortality of Non-implantable carioverter defibrillator (ICD) vs. ICD management in patients with heart failure with reduced ejection fraction (HFrEF).
Primary Outcome
Death from any cause
Conditions Studied
Interventions
- PROCEDURE ICD implantation
Study Locations (15)
New York
- Northwell Health - New York
- Nuvance Health Hudson Valley Cardiovascular Practice, PC - Poughkeepsie
- University of Rochester - Rochester
New Jersey
- Rutgers - New Brunswick
- The Valley Hospital - Paramus
Alberta
- University of Calgary - Calgary
- University of Alberta - Edmonton
Maine
- MaineHealth - Portland
Maryland
- Johns Hopkins University - Baltimore
Massachusetts
- Tufts Medical Center - Boston
Michigan
- Corewell Health - Grand Rapids
Minnesota
- Minneapolis Heart Institute Foundation - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,290 participants |
| Start Date | 2025-03-04 |
| Est. Completion | 2031-02-28 |
| Phase | NA |
What NCT06543446 shows while recruiting
NCT06543446 is an interventional study that assigns participants to a tested intervention. Its 3,290 participants enrollment target places it among the larger protocols in the corpus, below the 3,844-participant average among 27 other Heart Failure With Reduced Ejection Fraction trials with a reported enrollment target (14% lower).
The record links to 1 condition, with Heart Failure With Reduced Ejection Fraction appearing as the primary indexed condition, and to 1 intervention - of which ICD implantation is the first listed.
NCT06543446 lists 15 locations in 11 states (New York, New Jersey, Alberta).
Frequently Asked Questions
What is clinical trial NCT06543446 about?
NCT06543446 is a clinical study titled "Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy". The investigators aim to compare the risk of mortality of Non-implantable carioverter defibrillator (ICD) vs. ICD management in patients with heart failure with reduced ejection fraction (HFrEF).
What is the current status of trial NCT06543446?
This trial is currently recruiting. It is a NA study. The enrollment target is 3,290 participants. The study started on 2025-03-04. Estimated completion is 2031-02-28.
What conditions does trial NCT06543446 study?
This clinical trial studies the following conditions: Heart Failure With Reduced Ejection Fraction.
What interventions are being tested in trial NCT06543446?
The interventions under investigation include: ICD implantation (PROCEDURE).
Who is sponsoring clinical trial NCT06543446?
This trial is sponsored by University of Rochester, which has 636 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06543446 being conducted?
This trial has 15 study locations across Maine, Maryland, Massachusetts, Michigan, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure With Reduced Ejection Fraction
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06543446's enrollment target sits among peer trials
3,290 5th of 27 higher than 23 of 27 other Heart Failure With Reduced Ejection Fraction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure With Reduced Ejection Fraction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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