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NCT07215299 · ClinicalTrials.gov registry record · NA
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
A NA study of Healthy Volunteers, sponsored by Indiana University.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07215299: Recruiting NA study of Healthy Volunteers, sponsored by Indiana University.
NCT07215299 is a NA study of Healthy Volunteers that is actively recruiting participants, run by Indiana University. The registered enrollment target is 30 participants, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07215299, a NA study of Healthy Volunteers, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition. In the short term, the investigators aim to validate and characterize the effects of TI on brain activity as measured by fMRI and demonstrate its ability to focally stimulate deep brain regions without affecting overlying cortex. In the longer term, investigators aim to use these data to resolve longstanding debates about the function of deeper brain regions and lay the foundation for future clinical applications of TI for treating addiction, Obsessive-Compulsive Disorder (OCD), Parkinson's disease, and other disorders involving deep brain dysfunction. The grant supports 2 distinct aims, each of which will be evaluated through a series of independent studies.
Primary Outcome
Brain activity in the nucleus accumbens was measured using functional magnetic resonance imaging (fMRI) during active temporal interference (TI) brain stimulation compared to sham stimulation. Activity change from baseline (no stimulation) was quantified using region-of-interest (ROI) beta estimates extracted from the nucleus accumbens. The beta estimates were derived from blood-oxygen-level-dependent (BOLD) signal changes measured during fMRI and reflect the magnitude of task-related neural act
Conditions Studied
Interventions
- DEVICE Temporal Interference (TI) Electrical Stimulation - NAcc TI Active
- DEVICE Temporal Interference (TI) Electrical Stimulation - NAcc TI Sham
- DEVICE Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active
- DEVICE Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Sham
Study Locations (1)
Indiana
- Indiana University Bloomington, Imaging Research Facility - Bloomington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-11-12 |
| Est. Completion | 2027-02-02 |
| Phase | NA |
What NCT07215299 shows while recruiting
NCT07215299 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Healthy Volunteers appearing as the primary indexed condition, and to 4 interventions - of which Temporal Interference (TI) Electrical Stimulation - NAcc TI Active is the first listed.
NCT07215299 reports a single indexed study location in Indiana.
Frequently Asked Questions
What is clinical trial NCT07215299 about?
NCT07215299 is a clinical study titled "Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1". In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition. In the short term, the investigators aim to validate and characterize the effects of TI on brain...
What is the current status of trial NCT07215299?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-11-12. Estimated completion is 2027-02-02.
What conditions does trial NCT07215299 study?
This clinical trial studies the following conditions: Healthy Volunteers.
What interventions are being tested in trial NCT07215299?
The interventions under investigation include: Temporal Interference (TI) Electrical Stimulation - NAcc TI Active (DEVICE), Temporal Interference (TI) Electrical Stimulation - NAcc TI Sham (DEVICE), Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active (DEVICE), Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Sham (DEVICE).
Who is sponsoring clinical trial NCT07215299?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07215299 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT07215299's enrollment target sits among peer trials
30 187th of 283 higher than 87 of 283 other Healthy Volunteers trials
participants (enrollment target), bucketed by value
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