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Healthy Volunteers: early-phase trial registry
79 of 284 indexed Healthy Volunteers trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #32 of 28,707 conditions by registered trial count.
284 US clinical trials · 79 currently recruiting · #32 of 28,707 conditions by registered trial count
Healthy Volunteers: 284 US clinical trials tracked, 79 recruiting.
Healthy Volunteers is the subject of 284 registered US clinical trials on ClinicalTrials.gov, 79 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 206 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 16 of these trials.
Enrollment posture brief
Registry condition healthy-volunteers
OPEN 79 | RECR 28% | LATE 6 | EARLY 206 | RANK #32 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Arrhythmias, Cardiac (28% recruiting · 18 trials)
Healthy Volunteers lists 79 open slots (28% of 284 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Healthy Volunteers on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Healthy Volunteers is recruiting below its size-band peers.
79 of 284 indexed trials (27.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Healthy Volunteers trials is spread across many organizations.
Takeda accounts for 16 of 284 trials (5.6%). 144 distinct sponsors appear on at least one study for this condition label.
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Most Healthy Volunteers trials plan to enrol fewer than 100 people.
Median target enrolment is 48 among the 284 trials that report a genuine target (sentinel values excluded). 204 of those (71.8%) plan for fewer than 100 participants.
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Healthy Volunteers research is mostly interventional.
251 interventional and 33 observational studies make up this index (88.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
284 total, page 3 of 6
Long-Term Immunogenicity of the Norovirus GI.1/GII.4 Bivalent Virus-like Particle (VLP) Vaccine (NoV Vaccine) in Adults
Takeda
NCT03039790
A Study to Assess Immune Response to Multiple Doses of PF-06881894 or US-Approved Neulasta in Healthy Volunteers
Pfizer
NCT03273842
Providing Personally Tailored Dietary Suggestions Using Individual Microbiome and Glycemic Index Response.
Mayo Clinic
NCT02945514
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MA-0211 in Healthy Adult Subjects Including a Food Effect Cohort
Astellas Pharma Global Development
NCT03682484
A Study to Assess the Relative Bioavailability of Risankizumab Following Subcutaneous Administrations With a Pre-Filled Syringe or an On-Body Injector in Healthy Adult Participants
AbbVie
NCT07007091
Skin Safety Study to Evaluate the Sensitizing Potential in Healthy Volunteers
Maruho North America
NCT02256930
A Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants
Takeda
NCT03961308
Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines
National Heart, Lung, and Blood Institute (NHLBI)
NCT01191853
Immune Memory After Papillomavirus Vaccination
Emory University
NCT01505049
Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance
Northern California Institute of Research and Education
NCT01243060
Study to Evaluate the Relative Bioavailability of Two Risankizumab Drug Product Presentations in Healthy Volunteers.
AbbVie
NCT05567029
Single Dose Comparability Study of New and Current Dupilumab Drug Products Subcutaneously Administered in Healthy Adults
Sanofi
NCT05976386
Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers
Biogen
NCT01689116
Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
Massachusetts General Hospital
NCT00114114
Study of the Effect of Repeat Doses of Isavuconazole on Cardiac Repolarization
Astellas Pharma Global Development
NCT01565720
Impaired Wound Healing in Diabetic Foot Ulceration
Beth Israel Deaconess Medical Center
NCT00739323
Study to Assess Bioequivalence and Adhesion Properties Between Two Granisetron Transdermal Patches.
Kyowa Kirin
NCT05027646
A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants
Karuna Therapeutics
NCT06729970
The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) on QT Intervals in Healthy Volunteers
Purdue Pharma
NCT01148537
Study of the Safety and Tolerability of REGN2222(SAR438584) in Healthy Adult Volunteers
Regeneron Pharmaceuticals
NCT02121080
AZD8683 Single Ascending Dose Study
AstraZeneca
NCT00979849
Study to Evaluate the Pressor Effect of Oral Tyramine During Ozanimod Treatment in Healthy Adult Participants
Celgene
NCT04978298
A First-In-Human Study of TAK-004 in Healthy Adults
Takeda
NCT06236009
A Study of TAK-279 in Healthy Adults on the Effect on ECG Measurements
Takeda
NCT06258265
Phase 1 TAK-041 First-in-Human Safety, Tolerability, and Pharmacokinetics Study
Neurocrine Biosciences
NCT02748694
A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Needle Safety Device (PFS+NSD) in Healthy Participants
Takeda
NCT03948581
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP1617 in Healthy Adult Non-Asian and Japanese Subjects Including Assessment of a Food Effect
Astellas Pharma Global Development
NCT04077879
The Relationship Between Uric Acid and Inflammatory Markers
National Institute on Aging (NIA)
NCT01323335
Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively
Sanofi Pasteur, a Sanofi Company
NCT05050318
Phase 1, TAK-915-1001, Single-Rising Dose, Multiple-Rising Dose, Drug-Drug Interaction, Relative Bioavailability, Food Effect, and Effect on Elderly Participants Study
Takeda
NCT02461160
Guanfacine Immediate-release Electrocardiogram Results (QTc) Study
Shire
NCT00672984
A SAD and MAD Study of the Safety, Tolerability, and Pharmacokinetics of ATH-1105
LeonaBio
NCT06432647
Study in Healthy Volunteers to Establish the Bioequivalence of Two Different Manufacturers.
Biogen
NCT01632449
Bioequivalence Study Of Verapamil
Pfizer
NCT00668967
A Study to Assess the Safety and Tolerability of Single Ascending Doses of REGN1033(SAR391786)
Regeneron Pharmaceuticals
NCT01507402
Measure Exposure Of Tanezumab In Healthy Volunteers When Administering The Drug Subcutaneously
Pfizer
NCT00788294
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD)
AbbVie
NCT06024239
Self-regulation of Prefrontal Cortex During Emotional Cognitive Control
Laureate Institute for Brain Research
NCT04543500
Thorough QT Study of Nelfinavir
Pfizer
NCT00312182
Study of MORF 057 to Evaluate Single and Multi Ascending Doses in Healthy Volunteers
Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
NCT04580745
Growth Hormone Administration and the Human Immune System
National Institute on Aging (NIA)
NCT00663611
To Evaluate the Effect of AZD1722 on the Pharmacokinetics of Oral Midazolam in Healthy Volunteers
Ardelyx
NCT02140268
A Study of the Safety, Tolerability, and Bioequivalence of Orally Administered Venglustat in Healthy Adult Participants
Sanofi
NCT06418607
A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00353158
An Insulin Sensitivity Study in Healthy Subjects
Alkermes
NCT02922426
Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects.
Ablynx, a Sanofi company
NCT03172208
Crossover Study to Evaluate the Relative Bioavailability and Palatability of a Lenvatinib Suspension Compared to the Capsule Formulation in Adult Healthy Volunteers
Eisai
NCT02792829
A Phase 1a Trial Assessing the Safety, Tolerability, and Immunogenicity of GS-4774 (GI-13020) at Various Dose Levels and Regimens in Healthy Adults
Gilead Sciences
NCT01779505
A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
Cerevel Therapeutics
NCT05965219
Developing Biomarkers of Dietary Intake
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01237093
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 198 |
| Phase 2 | 8 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Healthy Volunteers records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Healthy Volunteers trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Healthy Volunteers page
284 registered trials, 79 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 79 Healthy Volunteers trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Takeda sponsors the most Healthy Volunteers trials on record, review their full trial history before evaluating a specific study. See Takeda's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Healthy Volunteers condition card totals 284 registered trials; most-linked intervention Placebo; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.