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NCT07204418 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
A Phase 1 study of Healthy Volunteers, sponsored by Karuna Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 56
- Enrollment target
- 3
- Study locations
NCT07204418: Recruiting Phase 1 study of Healthy Volunteers, sponsored by Karuna Therapeutics.
NCT07204418 is a Phase 1 study of Healthy Volunteers that is actively recruiting participants, run by Karuna Therapeutics. The registered enrollment target is 56 participants, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (88% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07204418, a Phase 1 study of Healthy Volunteers, is actively recruiting participants, sponsored by Karuna Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 56 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to evaluate the pharmacokinetics (PK) of xanomeline following administration of KarXT in CYP2D6 normal/extensive, intermediate, poor, and ultrarapid metabolizers.
Conditions Studied
Interventions
- DRUG Xanomeline/ Trospium Chloride
Study Locations (3)
California
- Anaheim Clinical Trials - Anaheim
Kansas
- ICON - Lenexa - Lenexa
Texas
- ICON Development Solutions - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2025-10-13 |
| Est. Completion | 2026-12-03 |
| Phase | Phase 1 |
What NCT07204418 shows while recruiting
NCT07204418 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 56 participants, a relatively small participant target, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Healthy Volunteers appearing as the primary indexed condition, and to 1 intervention - of which Xanomeline/ Trospium Chloride is the first listed.
NCT07204418 reports a single indexed study location in California, Kansas, Texas.
Frequently Asked Questions
What is clinical trial NCT07204418 about?
NCT07204418 is a clinical study titled "A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants". The purpose of this study is to evaluate the pharmacokinetics (PK) of xanomeline following administration of KarXT in CYP2D6 normal/extensive, intermediate, poor, and ultrarapid metabolizers.
What is the current status of trial NCT07204418?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 56 participants. The study started on 2025-10-13. Estimated completion is 2026-12-03.
What conditions does trial NCT07204418 study?
This clinical trial studies the following conditions: Healthy Volunteers.
What interventions are being tested in trial NCT07204418?
The interventions under investigation include: Xanomeline/ Trospium Chloride (DRUG).
Who is sponsoring clinical trial NCT07204418?
This trial is sponsored by Karuna Therapeutics, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07204418 being conducted?
This trial has 3 study locations across California, Kansas, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy Volunteers
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07204418's enrollment target sits among peer trials
56 129th of 283 higher than 152 of 283 other Healthy Volunteers trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Volunteers trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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