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NCT07204418 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
A Phase 1 study of Healthy Volunteers, sponsored by Karuna Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 56
- Enrollment target
- 3
- Study locations
NCT07204418 is a Phase 1 study of Healthy Volunteers that is actively recruiting participants, run by Karuna Therapeutics. The registered enrollment target is 56 participants, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (88% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT07204418, a Phase 1 study of Healthy Volunteers, is actively recruiting participants, sponsored by Karuna Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 56 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to evaluate the pharmacokinetics (PK) of xanomeline following administration of KarXT in CYP2D6 normal/extensive, intermediate, poor, and ultrarapid metabolizers.
Conditions Studied
Interventions
- DRUG Xanomeline/ Trospium Chloride
Study Locations (3)
California
- Anaheim Clinical Trials - Anaheim
Kansas
- ICON - Lenexa - Lenexa
Texas
- ICON Development Solutions - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2025-10-13 |
| Est. Completion | 2026-12-03 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07204418
The ClinicalTrials.gov registry entry for NCT07204418 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 56 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (88% lower). The listed sponsor is Karuna Therapeutics, which has 11 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy Volunteers appearing as the primary indexed condition, and to 1 intervention - of which Xanomeline/ Trospium Chloride is the first listed.
NCT07204418 reports 3 study locations spanning 3 distinct geographic areas - top geographies include California, Kansas, Texas.
Frequently Asked Questions
What is clinical trial NCT07204418 about?
NCT07204418 is a clinical study titled "A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants". The purpose of this study is to evaluate the pharmacokinetics (PK) of xanomeline following administration of KarXT in CYP2D6 normal/extensive, intermediate, poor, and ultrarapid metabolizers.
What is the current status of trial NCT07204418?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 56 participants. The study started on 2025-10-13. Estimated completion is 2026-12-03.
What conditions does trial NCT07204418 study?
This clinical trial studies the following conditions: Healthy Volunteers.
What interventions are being tested in trial NCT07204418?
The interventions under investigation include: Xanomeline/ Trospium Chloride (DRUG).
Who is sponsoring clinical trial NCT07204418?
This trial is sponsored by Karuna Therapeutics, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07204418 being conducted?
This trial has 3 study locations across California, Kansas, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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