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NCT06980428 · ClinicalTrials.gov registry record · Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia
A Phase 1 study of Healthy Participants and Dyslipidemia, sponsored by AstraZeneca.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 136
- Enrollment target
- 5
- Study locations
NCT06980428 is a Phase 1 study of Healthy Participants and Dyslipidemia that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 136 participants, above the 64-participant average among 119 other Healthy Participants trials with a reported enrollment target (113% higher). The trial reports 5 study locations across 4 states.
The verdict
NCT06980428, a Phase 1 study of Healthy Participants and Dyslipidemia, is actively recruiting participants, sponsored by AstraZeneca.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 136 participants
- Enrollment target
- 5
- Study locations
Study Summary
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending doses of AZD4954 in healthy participants with or without elevated Lipoprotein(a) (Lp\[a\]) levels and participants with dyslipidemia.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG AZD4954
Study Locations (5)
Florida
- Research Site - Inverness
- Research Site - Jacksonville
California
- Research Site - Glendale
Maryland
- Research Site - Brooklyn
Texas
- Research Site - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 136 participants |
| Start Date | 2025-05-27 |
| Est. Completion | 2026-12-04 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06980428
The ClinicalTrials.gov registry entry for NCT06980428 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 136 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 64-participant average among 119 other Healthy Participants trials with a reported enrollment target (113% higher). The listed sponsor is AstraZeneca, which has 1,285 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Healthy Participants appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06980428 reports 5 study locations spanning 4 distinct geographic areas - top geographies include Florida, California, Maryland.
Frequently Asked Questions
What is clinical trial NCT06980428 about?
NCT06980428 is a clinical study titled "A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia". The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending doses of AZD4954 in healthy participants with or without elevated Lipoprotein(a) (Lp\[a\]) levels and participants with dyslipidemia.
What is the current status of trial NCT06980428?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 136 participants. The study started on 2025-05-27. Estimated completion is 2026-12-04.
What conditions does trial NCT06980428 study?
This clinical trial studies the following conditions: Healthy Participants, Dyslipidemia.
What interventions are being tested in trial NCT06980428?
The interventions under investigation include: Placebo (DRUG), AZD4954 (DRUG).
Who is sponsoring clinical trial NCT06980428?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06980428 being conducted?
This trial has 5 study locations across California, Florida, Maryland, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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