Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Headache: full-pipeline trial registry
17 of 37 indexed Headache trials are currently recruiting.
Corpus placement: #406 of 28,707 conditions by registered trial count.
37 US clinical trials · 17 currently recruiting · #406 of 28,707 conditions by registered trial count
Headache: 37 US clinical trials tracked, 17 recruiting.
Headache is the subject of 37 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Seattle Children's Hospital, running 3 of these trials.
Enrollment posture brief
Registry condition headache
OPEN 17 | RECR 46% | LATE 5 | EARLY 6 | RANK #406 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Depressive Symptoms (46% recruiting · 61 trials)
Headache lists 17 open slots (46% of 37 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Headache on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Headache is recruiting above its size-band peers.
17 of 37 indexed trials (45.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Headache trials is spread across many organizations.
Seattle Children's Hospital accounts for 3 of 37 trials (8.1%). 30 distinct sponsors appear on at least one study for this condition label.
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Typical Headache enrolment sits around 85 participants.
Median target enrolment is 85 among the 36 trials that report a genuine target (sentinel values excluded). 20 of those (55.6%) plan for fewer than 100 participants.
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Headache research is mostly interventional.
31 interventional and 6 observational studies make up this index (83.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
37 total, page 1 of 1
External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
Cefaly Technology
NCT06788977
Responding With Evidence and Access for Childhood Headaches
Children's Hospital Medical Center, Cincinnati
NCT05889624
Mind Body Balance for Pediatric Migraine
Children's Hospital Medical Center, Cincinnati
NCT04715685
Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches
Veterans Medical Research Foundation
NCT05176392
BLOCK-SAH - PPF-Block for Post-SAH Headache
University of Florida
NCT06008795
Placebo Impacts Sleep and Pain Modulation in Chronic Pain
University of Maryland, Baltimore
NCT06225817
Puberty, Testosterone, and Brain Development
University of Colorado, Denver
NCT06670053
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
University of California, Los Angeles
NCT06073886
Determining the Utility of a Behavioral Intervention in Chronic Migraine
Mayo Clinic
NCT05415020
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
State University of New York - Upstate Medical University
NCT06112093
Concussion Recovery and Support Program
Seattle Children's Hospital
NCT07097792
Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache
University of California, Davis
NCT06621329
The Effect of Osteopathic Treatment on Craniocervico-Mandibular Dysfunction
Edward Via Virginia College of Osteopathic Medicine
NCT06471426
Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
Northwell Health
NCT04685772
Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches
University of Kansas Medical Center
NCT06582810
Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage
Wright State University
NCT07116408
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The University of Texas Medical Branch, Galveston
NCT07294118
Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty
University of Colorado, Denver
NCT05607303
Sphenopalatine Ganglion Block and Cold Induced Headaches
Wright State University
NCT06310200
An Intervention to Improve Adolescent Headache Self-management
Stephen F Butler, PhD
NCT02475005
Study of Two Digital Therapeutics for the Prevention of Episodic Migraine
Click Therapeutics
NCT05853900
Equity in Diagnostic Imaging Trial
Icahn School of Medicine at Mount Sinai
NCT01611714
Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines
Wake Forest University Health Sciences
NCT05967442
A Randomized Controlled Trial of Best Approach to Care Compared to Diversified Chiropractic Adjustive Technique
Parker College of Chiropractic
NCT00163124
Olanzapine for Acute Headaches
HealthPartners Institute
NCT03066622
Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain
Seattle Children's Hospital
NCT01496378
Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)
Click Therapeutics
NCT06004388
Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department
University of Medicine and Dentistry of New Jersey
NCT00856232
Mechanisms Of Change in Adolescent Pain Self-management
Seattle Children's Hospital
NCT04043962
Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache
Western University of Health Sciences
NCT01332864
Cervical Spine Manipulation Affects on Balance and Proprioception
University of Nevada, Las Vegas
NCT01745705
Ketamine for Acute Migraine in the Emergency Department
Carilion Clinic
NCT02697071
GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
Boston Children's Hospital
NCT01974791
STOPAIN in the Treatment of a Single Migraine Attack
Thomas Jefferson University
NCT01687101
Non-Rhinologic Etiologies of Headaches and Facial Pain in Tertiary Care Setting
Penn State University
NCT00355160
Vagal Nerve Stimulation for Post COVID Fatigue
Mayo Clinic
NCT05445427
Psychological Assessment and Treatment of Chronic Benign Headache
US Department of Veterans Affairs
NCT00018811
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 4 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Headache records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Headache trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Headache page
37 registered trials, 17 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 17 Headache trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Seattle Children's Hospital sponsors the most Headache trials on record, review their full trial history before evaluating a specific study. See Seattle Children's Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Headache condition card totals 37 registered trials; most-linked intervention Click Digital Therapeutic; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.