Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Chronic Obstructive Pulmonary Disease (COPD)

Open-data reference.

35 US clinical trials · 10 currently recruiting

Active & Recent Trials

RECRUITING 2,000 participants

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

Weill Medical College of Cornell University

NCT01776398

RECRUITING Phase 3 1,290 participants

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Hoffmann-La Roche

NCT05595642

RECRUITING Phase 2 1,160 participants

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

AstraZeneca

NCT07082738

RECRUITING 1,000 participants

Temple Health Chest Initiative (THCI 2.0)

Temple University

NCT06933758

RECRUITING Phase 3 990 participants

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

AstraZeneca

NCT06878261

RECRUITING Phase 3 990 participants

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

AstraZeneca

NCT06883305

RECRUITING Phase 3 770 participants

Multi-Center Clean Air Randomized Controlled Trial in COPD

JHSPH Center for Clinical Trials

NCT06376994

RECRUITING Phase 2 334 participants

Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

Johns Hopkins University

NCT07059091

RECRUITING 128 participants

Effectiveness of the WearME System for COPD Severity and Respiratory Function

LASARRUS Clinic and Research Center

NCT06751537

RECRUITING 111 participants

Functional Social Support in COPD Self-Management

Medical University of South Carolina

NCT07353034

ACTIVE NOT RECRUITING Phase 3 1,713 participants

Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).

AstraZeneca

NCT05742802

ACTIVE NOT RECRUITING Phase 3 1,454 participants

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

AstraZeneca

NCT06040086

ACTIVE NOT RECRUITING Phase 3 1,172 participants

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.

AstraZeneca

NCT05158387

ACTIVE NOT RECRUITING Phase 3 1,132 participants

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

AstraZeneca

NCT05166889

COMPLETED NA 2,004 participants

The CAPTURE Study: Validating a Unique COPD Case Finding Tool in Primary Care (Aim 3)

Weill Medical College of Cornell University

NCT03583099

COMPLETED Phase 3 1,142 participants

Efficacy and Safety of Indacaterol Plus Tiotropium Versus Tiotropium Alone in Patients With Chronic Obstructive Pulmonary Disease

Novartis Pharmaceuticals

NCT00877383

COMPLETED Phase 3 1,087 participants

A Long-Term Safety Trial of Treatment With Nebulized SUN-101 in Patients With COPD

Sunovion Respiratory Development

NCT02276222

COMPLETED Phase 3 1,060 participants

A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Mylan

NCT02518139

COMPLETED Phase 3 1,042 participants

A 12 Week Treatment, Multi-center, Randomized, Double-blind, Parallel-group, Placebo and Active Controlled Study to Assess the Efficacy, Safety, and Tolerability of Indacaterol Maleate / Glycopyrronium Bromide in COPD Patients With Moderate to Severe Airflow Limitation.

Novartis Pharmaceuticals

NCT01727141

COMPLETED Phase 3 611 participants

Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD)

Mylan

NCT02512510

COMPLETED Phase 3 317 participants

Open-Label Assessment of the Albuterol Spiromax® Dry Powder Inhaler (DPI)

Teva Branded Pharmaceutical Products R&D

NCT01857323

COMPLETED NA 307 participants

Stepping up to Health - for Veterans With Chronic Obstructive Pulmonary Disease (COPD)

VA Office of Research and Development

NCT01102777

COMPLETED Phase 2 281 participants

Safety and Tolerability of 28 Days Treatment With Glycopyrronium Bromide (NVA237) (100 or 200 µg Once a Day) in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Novartis

NCT00510510

COMPLETED NA 192 participants

Aides in Respiration Health Coaching for COPD

University of California, San Francis

NCT02234284

COMPLETED Phase 2 137 participants

A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis

AstraZeneca

NCT04631016

COMPLETED Phase 2 116 participants

Tiotropium Bromide Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease

Nephron Pharmaceuticals Corporation

NCT04780984

COMPLETED 114 participants

Use of Respiratory Therapists (RTs) to Improve Outcomes and Quality of Life in Patients With COPD

StratiHealth

NCT02078622

COMPLETED NA 90 participants

Tai Chi After Pulmonary Rehabilitation in Patients With COPD: A Randomized Trial

Beth Israel Deaconess Medical Center

NCT01998724

COMPLETED Phase 2 60 participants

Sodium Pyruvate Therapy in COPD Patients

Emphy

NCT00262613

COMPLETED Phase 1 47 participants

A Study to Assess Drug Absorption of Fixed Dose Combinations of Budesonide, Glycopyrronium, and Formoterol

AstraZeneca

NCT04600505

COMPLETED NA 46 participants

Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers

Weill Medical College of Cornell University

NCT00565214

COMPLETED Phase 4 44 participants

A Clinical Study to Investigate if a Single Dose of an Approved Drug Product (Glycopyrrolate Inhalation Solution) Reduces Trapped Air in the Lungs of Participants With Chronic Obstructive Pulmonary Disease.

Sunovion Respiratory Development

NCT04155047

COMPLETED NA 24 participants

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

University of North Carolina, Chapel Hill

NCT01615484

COMPLETED NA 23 participants

Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation

Breas Medical

NCT06560411

COMPLETED Phase 2 11 participants

Safety Study of CTX-100 Inhalation Solution (Formerly ETX-100)

Turino, Gerard, M.D.

NCT00993707

Phase Distribution

PhaseTrial count
Early Phase 1 1
Phase 2 7
Phase 3 14
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Obstructive Pulmonary Disease (COPD) Trial Landscape

ClinicalTrials.gov lists 35 US studies indexed under Chronic Obstructive Pulmonary Disease (COPD), and 10 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Obstructive Pulmonary Disease (COPD) shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Obstructive Pulmonary Disease (COPD) is led by AstraZeneca with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 35 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Obstructive Pulmonary Disease (COPD)?

PlainTrial tracks 35 US clinical trials for Chronic Obstructive Pulmonary Disease (COPD), of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Obstructive Pulmonary Disease (COPD)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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