Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Biliary Tract Cancer

Open-data reference.

37 US clinical trials · 24 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 1,100 participants

A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)

AstraZeneca

NCT07221253

RECRUITING Phase 3 620 participants

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

AstraZeneca

NCT06467357

RECRUITING Phase 2 454 participants

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

AstraZeneca

NCT05489211

RECRUITING NA 360 participants

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Cedars-Sinai Medical Center

NCT04907643

RECRUITING Phase 2 294 participants

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

AstraZeneca

NCT05775159

RECRUITING Phase 3 286 participants

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Jazz Pharmaceuticals

NCT06282575

RECRUITING Phase 1 280 participants

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

SystImmune

NCT06293898

RECRUITING Phase 2 224 participants

AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

AstraZeneca

NCT06219941

RECRUITING Phase 1 220 participants

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Merck Sharp & Dohme

NCT06428409

RECRUITING Phase 1 145 participants

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

NextCure

NCT06774963

RECRUITING Phase 1 140 participants

Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors

TiumBio Co.

NCT05784688

RECRUITING Phase 1 120 participants

Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects With Solid Tumors

SystImmune

NCT07021066

RECRUITING Phase 1 117 participants

Study for AZD4360 in Participants With Advanced Solid Tumours

AstraZeneca

NCT06921928

RECRUITING Phase 1 115 participants

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

ModeX Therapeutics, An OPKO Health Company

NCT06239194

RECRUITING 105 participants

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

AstraZeneca

NCT06973161

RECRUITING Phase 2 70 participants

Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

Massachusetts General Hospital

NCT03482102

RECRUITING Phase 2 64 participants

Ligufalimab and Cadonilimab in Advanced Liver Cancers

University of Texas Southwestern Medical Center

NCT06789848

RECRUITING Phase 2 60 participants

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

Replimune

NCT05733598

RECRUITING Phase 2 59 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers

Udai Kammula

NCT03801083

RECRUITING NA 48 participants

Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

NCT06731998

RECRUITING Phase 1 33 participants

Phase 1 Trial of ZM008 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Zumutor Biologics

NCT06451497

RECRUITING Phase 1 27 participants

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

Tanabe Pharma America

NCT06943521

RECRUITING Phase 2 27 participants

Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer

Case Comprehensive Cancer Center

NCT07146646

RECRUITING Phase 1 15 participants

Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer

University of Maryland, Baltimore

NCT06546969

ACTIVE NOT RECRUITING 1,810 participants

Extracellular RNA Markers of Liver Disease and Cancer

Mayo Clinic

NCT02908048

ACTIVE NOT RECRUITING Phase 3 757 participants

Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)

AstraZeneca

NCT06109779

ACTIVE NOT RECRUITING Phase 2 309 participants

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Eli Lilly and Company

NCT02711553

ACTIVE NOT RECRUITING Phase 2 150 participants

A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)

Compass Therapeutics

NCT05506943

ACTIVE NOT RECRUITING Phase 3 142 participants

Durvalumab With Chemotherapy as First Line Treatment in Patients With Advanced Biliary Tract Cancers (aBTCs)

AstraZeneca

NCT05771480

ACTIVE NOT RECRUITING Phase 1 90 participants

A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer

Fujifilm Pharmaceuticals U.S.A.

NCT03440450

ACTIVE NOT RECRUITING Phase 1 48 participants

CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

Carisma Therapeutics

NCT04660929

ACTIVE NOT RECRUITING Phase 2 27 participants

XmAb20717 in Advanced Biliary Tract Cancers

Abramson Cancer Center at Penn Medicine

NCT05297903

ACTIVE NOT RECRUITING Phase 1 24 participants

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

University of Nebraska

NCT05220046

COMPLETED Phase 2 162 participants

A Study of Atezolizumab With or Without Bevacizumab in Combination With Cisplatin Plus Gemcitabine in Patients With Untreated, Advanced Biliary Tract Cancer

Hoffmann-La Roche

NCT04677504

COMPLETED Phase 1 55 participants

A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

Hoffmann-La Roche

NCT04338685

COMPLETED Phase 2 54 participants

Study of Nivolumab in Patients With Advanced Refractory Biliary Tract Cancers

H. Lee Moffitt Cancer Center and Research Institute

NCT02829918

COMPLETED Phase 2 8 participants

Capecitabine, Oxaliplatin, Bevacizumab and Radiation Therapy in Patients With Biliary Tract and Gallbladder Cancer

Massachusetts General Hospital

NCT00142480

Phase Distribution

PhaseTrial count
Early Phase 1 14
Phase 2 14
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Biliary Tract Cancer Trial Landscape

ClinicalTrials.gov lists 37 US studies indexed under Biliary Tract Cancer, and 24 of those are currently open to recruitment — roughly 65% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Biliary Tract Cancer shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Biliary Tract Cancer is led by AstraZeneca with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 37 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Biliary Tract Cancer?

PlainTrial tracks 37 US clinical trials for Biliary Tract Cancer, of which 24 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Biliary Tract Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →