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ACTIVE NOT RECRUITING Phase 2

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma

NCT05909904 · View on ClinicalTrials.gov ↗

Study Summary

This study is designed to evaluate the efficacy and safety of tislelizumab and tislelizumab in combination with investigational agent(s) in first-line recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).

Interventions

  • DRUG Tislelizumab
  • DRUG LBL-007
  • DRUG BGB-A425

Study Locations (20)

California

  • Valkyrie Clinical Trials — Los Angeles
  • Stanford Medicine — Stanford

Florida

  • Florida Cancer Specialist Research Institute Lake Nona — Orlando
  • Florida Cancer Specialist Research Institute Panhandle — Tallahassee

Washington

  • Cancer Care Northwest — Spokane Valley
  • Northwest Cancer Specialist, Pc(Us Oncology Research) — Vancouver

New South Wales

  • Nepean Hospital — Kingswood
  • North Shore Private Hospital — St Leonards

Queensland

  • Gold Coast Private Hospital — Gold Coast
  • Greenslopes Private Hospital — Greenslopes

Colorado

  • Rocky Mountain Cancer Centers, Llp(Us Oncology Research) — Lone Tree

Kentucky

  • University of Kentucky Markey Cancer Center — Lexington

Virginia

  • Oncology and Hematology Associates of Southwest Virginia, Inc (Us Oncology Research) — Blacksburg

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2023-07-21
Est. Completion 2026-05-28
Phase Phase 2

Sponsor

BeiGene

91 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05909904

The ClinicalTrials.gov registry entry for NCT05909904 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Head and Neck Cancer appearing as the primary indexed condition, and to 3 interventions — of which Tislelizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05909904 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Florida, Washington. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05909904 about?

NCT05909904 is a clinical study titled "A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma". This study is designed to evaluate the efficacy and safety of tislelizumab and tislelizumab in combination with investigational agent(s) in first-line recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).

What is the current status of trial NCT05909904?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2023-07-21. Estimated completion is 2026-05-28.

What conditions does trial NCT05909904 study?

This clinical trial studies the following conditions: Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05909904?

The interventions under investigation include: Tislelizumab (DRUG), LBL-007 (DRUG), BGB-A425 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05909904?

This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05909904 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Kentucky, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial