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ClinicalTrials.gov 71 recruiting now official registry

Head and Neck Squamous Cell Carcinoma clinical trials

71 of 125 indexed Head and Neck Squamous Cell Carcinoma trials are currently recruiting.

125 US clinical trials · 71 currently recruiting

Head and Neck Squamous Cell Carcinoma is the subject of 125 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 5 of these trials.

The research picture

Head and Neck Squamous Cell Carcinoma has 125 registered US clinical trials, 71 of them open to new participants right now, about 57% of the total.

71
recruiting participants now
57%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
5
top sponsor: AstraZeneca
Phase 168Phase 243Phase 33Phase 41

Active & Recent Trials

125 total, page 3 of 3

ACTIVE NOT RECRUITING Phase 1 24 participants

Avelumab, Cetuximab, and Palbociclib in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Kathryn Gold

NCT03498378

ACTIVE NOT RECRUITING Phase 2 24 participants

Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck Ca

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04848116

ACTIVE NOT RECRUITING Phase 1 22 participants

Neoadjuvant Immunoradiotherapy in Head & Neck Cancer

Providence Health & Services

NCT03247712

ACTIVE NOT RECRUITING Phase 2 20 participants

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Trisha Wise-Draper

NCT04414540

ACTIVE NOT RECRUITING Phase 1 18 participants

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

Megan Daly, MD

NCT03474497

ACTIVE NOT RECRUITING Phase 2 18 participants

HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma

Dan Zandberg

NCT04369937

ACTIVE NOT RECRUITING Phase 1 16 participants

QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.

NantBioScience

NCT03552718

ACTIVE NOT RECRUITING Phase 1 15 participants

Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1

TILT Biotherapeutics

NCT05222932

ACTIVE NOT RECRUITING Phase 1 14 participants

Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer

American College of Radiology

NCT05540899

ACTIVE NOT RECRUITING Phase 1 12 participants

Phase Ib of L-NMMA and Pembrolizumab

The Methodist Hospital Research Institute

NCT03236935

ACTIVE NOT RECRUITING Phase 1 11 participants

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

City of Hope Medical Center

NCT02432963

ACTIVE NOT RECRUITING Phase 1 6 participants

A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers

Pfizer

NCT06870487

COMPLETED NA 112 participants

Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps

University of California, Davis

NCT03340038

COMPLETED Phase 2 81 participants

Cetuximab With or Without Tivantinib in Treating Patients With Head and Neck Cancer That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01696955

COMPLETED Phase 1 64 participants

Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced Cancers

Tvardi Therapeutics, Incorporated

NCT03195699

COMPLETED Phase 2 42 participants

Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475

University of Southern California

NCT03049618

COMPLETED Phase 2 30 participants

A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer

OncoNano Medicine

NCT03735680

COMPLETED Phase 1 26 participants

Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma

Baylor College of Medicine

NCT02949700

COMPLETED Phase 2 26 participants

Preoperative Immune Checkpoint Inhibitor for Patients With Primary Untreated or Recurrent/Metastatic SCCHN

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03878979

COMPLETED Phase 1 24 participants

Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer

National Cancer Institute (NCI)

NCT01711541

COMPLETED Phase 1 21 participants

A Study to Investigate Biomarker Effects of Pre-Surgical Treatment With DNA Damage Repair (DDR) Agents in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC).

AstraZeneca

NCT03022409

COMPLETED Phase 1 19 participants

A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors

Cantargia AB

NCT04452214

COMPLETED Early Phase 1 15 participants

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC

Presage Biosciences

NCT06062602

COMPLETED Early Phase 1 8 participants

A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Pure Biologics S.A.

NCT06273852

COMPLETED Phase 2 7 participants

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

University of California, San Diego

NCT03993353

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Phase Distribution

PhaseTrial count
Phase 1 68
Phase 2 43
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Head and Neck Squamous Cell Carcinoma Trial Landscape

125 indexed Head and Neck Squamous Cell Carcinoma studies · 71 recruiting (57%).

Phase mix: 4 late (III/IV) vs 111 early (I/II).

Top sponsor: AstraZeneca (5 trials), 9 others listed. 25 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Head and Neck Squamous Cell Carcinoma?

PlainTrial tracks 125 US clinical trials for Head and Neck Squamous Cell Carcinoma, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Head and Neck Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.