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Head and Neck Carcinoma: early-phase trial registry
17 of 31 indexed Head and Neck Carcinoma trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #495 of 28,707 conditions by registered trial count.
31 US clinical trials · 17 currently recruiting · #495 of 28,707 conditions by registered trial count
Head and Neck Carcinoma: 31 US clinical trials tracked, 17 recruiting.
Head and Neck Carcinoma is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 10 of these trials.
Enrollment posture brief
Registry condition head-and-neck-carcinoma
OPEN 17 | RECR 55% | LATE 0 | EARLY 11 | RANK #495 | SPON 10
Volume-matched condition peers
Nearest open-share peer: Peripheral Artery Disease (55% recruiting · 51 trials)
Head and Neck Carcinoma lists 17 open slots (55% of 31 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Head and Neck Carcinoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Head and Neck Carcinoma is recruiting above its size-band peers.
17 of 31 indexed trials (54.8%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Head and Neck Carcinoma research.
M.D. Anderson Cancer Center accounts for 10 of 31 trials (32.3%). 18 distinct sponsors appear on at least one study for this condition label.
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Typical Head and Neck Carcinoma enrolment sits around 50 participants.
Median target enrolment is 50 among the 31 trials that report a genuine target (sentinel values excluded). 18 of those (58.1%) plan for fewer than 100 participants.
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Head and Neck Carcinoma research is mostly interventional.
24 interventional and 7 observational studies make up this index (77.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
31 total, page 1 of 1
Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy
M.D. Anderson Cancer Center
NCT00991094
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Alliance for Clinical Trials in Oncology
NCT05334069
Cancer Genetic Testing in Ethnic Populations
Mayo Clinic
NCT04475640
Oropharynx (OPX) Biomarker Trial
Mayo Clinic
NCT06356272
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
VM Oncology
NCT03556228
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
Mayo Clinic
NCT05075980
Customized 3D Printed Oral Stents During Head and Neck Radiotherapy
M.D. Anderson Cancer Center
NCT04870762
Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy
Covenant Health Cancer Center
NCT06183268
A Financial Intervention (Financial Compass) to Identify and Address Financial Hardship Among Head and Neck Cancer Patients, Financial Compass Trial
Roswell Park Cancer Institute
NCT06896695
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence
University of Southern California
NCT06420219
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)
Jonsson Comprehensive Cancer Center
NCT06572423
Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers
City of Hope Medical Center
NCT06985784
Tongue-out Radiation Therapy (TORT) for the Mitigation of Radiotherapy-related Toxicities in Patients With Head and Neck Cancer
Yvonne Mowery
NCT07227792
Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer
University of Chicago
NCT05526924
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
Jonsson Comprehensive Cancer Center
NCT07118176
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Case Comprehensive Cancer Center
NCT06627270
A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer
Memorial Sloan Kettering Cancer Center
NCT05544136
Predicting Radiological Extranodal Extension in Oropharyngeal Carcinoma Patients Using AI
Maastricht Radiation Oncology
NCT05565313
Medical Data Collection of Patients With Head and Neck Cancer Treated With Proton Therapy
M.D. Anderson Cancer Center
NCT01627093
Dyadic Yoga Intervention for the Improvement of Healthcare Utilization and Quality of Life in Patients With Head and Neck Cancer Undergoing Chemoradiation and Their Caregivers
M.D. Anderson Cancer Center
NCT04890834
Clinical Data Collection in Studying Clinical Factors Associated With Post-Surgery Chronic Opioid Use in Patients With Head and Neck Cancers
M.D. Anderson Cancer Center
NCT03888651
Bioelectrical Impedance Analysis in Estimating Body Composition in Patients With Stage I-IV Head and Neck Cancer Undergoing Radiation Therapy
M.D. Anderson Cancer Center
NCT02615275
High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors
M.D. Anderson Cancer Center
NCT04151082
Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues
Jonsson Comprehensive Cancer Center
NCT04147494
Interdisciplinary Interventions to Address Pain Management Among Head and Neck Cancer Patients
M.D. Anderson Cancer Center
NCT05077072
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors
M.D. Anderson Cancer Center
NCT03612531
Neurofeedback in Decreasing Acute Radiotherapy-Induced Pain in Patients With Head and Neck Cancer
M.D. Anderson Cancer Center
NCT02543320
Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps
University of California, Davis
NCT03340038
Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment
Thomas Jefferson University
NCT04788264
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
University of California, San Diego
NCT03993353
Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy
OHSU Knight Cancer Institute
NCT03135782
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Head and Neck Carcinoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Head and Neck Carcinoma trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Head and Neck Carcinoma page
31 registered trials, 17 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 17 Head and Neck Carcinoma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Head and Neck Carcinoma trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Head and Neck Carcinoma condition card totals 31 registered trials; most-linked intervention Questionnaire Administration; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.