Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

NCT05075980 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radiation to the tumor and has the potential to reduce treatment-related side effects. IMRT is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of x-ray radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. IMPT may work as well as IMRT after surgery in treating patients with head and neck cancer.

Interventions

  • PROCEDURE Computed Tomography
  • DRUG Cisplatin
  • OTHER Quality-of-Life Assessment
  • OTHER Questionnaire Administration
  • PROCEDURE Intensity-Modulated Proton Therapy

Study Locations (9)

Minnesota

  • Mayo Clinic Health System in Albert Lea — Albert Lea
  • Mayo Clinic Health System - Mankato — Mankato
  • Mayo Clinic Radiation Therapy - Northfield — Northfield
  • Mayo Clinic in Rochester — Rochester

Arizona

  • Mayo Clinic Hospital in Arizona — Phoenix
  • Mayo Clinic in Arizona — Scottsdale

Wisconsin

  • Mayo Clinic Health System - Eau Claire — Eau Claire
  • Mayo Clinic Health System - Franciscan Healthcare — La Crosse

Florida

  • Mayo Clinic in Florida — Jacksonville

Trial Details

FieldValue
Enrollment Target 174 participants
Start Date 2022-02-16
Est. Completion 2035-11-15
Phase Phase 2

Sponsor

Mayo Clinic

3,246 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05075980

The ClinicalTrials.gov registry entry for NCT05075980 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 174 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 3,246 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Head and Neck Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Computed Tomography is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05075980 reports 9 study locations spanning 4 distinct geographic areas — top geographies include Minnesota, Arizona, Wisconsin. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05075980 about?

NCT05075980 is a clinical study titled "Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study". This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radia...

What is the current status of trial NCT05075980?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 174 participants. The study started on 2022-02-16. Estimated completion is 2035-11-15.

What conditions does trial NCT05075980 study?

This clinical trial studies the following conditions: Head and Neck Carcinoma, Oropharyngeal Carcinoma, Head and Neck Carcinoma of Unknown Primary, Oral Cavity Carcinoma, Metastatic Malignant Neoplasm in the Lymph Nodes. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05075980?

The interventions under investigation include: Computed Tomography (PROCEDURE), Cisplatin (DRUG), Quality-of-Life Assessment (OTHER), Questionnaire Administration (OTHER), Intensity-Modulated Proton Therapy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05075980?

This trial is sponsored by Mayo Clinic, which has 3,246 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05075980 being conducted?

This trial has 9 study locations across Arizona, Florida, Minnesota, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial