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NCT05075980 · ClinicalTrials.gov registry record · Phase 2
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
A Phase 2 study of Head and Neck Carcinoma and Oropharyngeal Carcinoma, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 174
- Enrollment target
- 9
- Study locations
NCT05075980: Recruiting Phase 2 study of Head and Neck Carcinoma and Oropharyngeal Carcinoma, sponsored by Mayo Clinic.
NCT05075980 is a Phase 2 study of Head and Neck Carcinoma and Oropharyngeal Carcinoma that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 174 participants, below the 408-participant average among 30 other Head and Neck Carcinoma trials with a reported enrollment target (57% lower). The trial reports 9 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05075980, a Phase 2 study of Head and Neck Carcinoma and Oropharyngeal Carcinoma, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 174 participants
- Enrollment target
- 9
- Study locations
Study Summary
This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radiation to the tumor and has the potential to reduce treatment-related side effects. IMRT is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of x-ray radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. IMPT may work as well as IMRT after surgery in treating patients with head and neck cancer.
Primary Outcome
The 2-year LRF rate will be estimated by counting the number of patients with a local or regional failure and dividing by the total number of eligible patients.
Conditions Studied
Interventions
- PROCEDURE Computed Tomography
- DRUG Cisplatin
- OTHER Quality-of-Life Assessment
- OTHER Questionnaire Administration
- PROCEDURE Intensity-Modulated Proton Therapy
Study Locations (9)
Minnesota
- Mayo Clinic Health System in Albert Lea - Albert Lea
- Mayo Clinic Health System - Mankato - Mankato
- Mayo Clinic Radiation Therapy - Northfield - Northfield
- Mayo Clinic in Rochester - Rochester
Arizona
- Mayo Clinic Hospital in Arizona - Phoenix
- Mayo Clinic in Arizona - Scottsdale
Wisconsin
- Mayo Clinic Health System - Eau Claire - Eau Claire
- Mayo Clinic Health System - Franciscan Healthcare - La Crosse
Florida
- Mayo Clinic in Florida - Jacksonville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 174 participants |
| Start Date | 2022-02-16 |
| Est. Completion | 2035-11-15 |
| Phase | Phase 2 |
What NCT05075980 shows while recruiting
NCT05075980 is an interventional study that assigns participants to a tested intervention. The registered 174 participants enrollment target is mid-sized for trials with a published cap, below the 408-participant average among 30 other Head and Neck Carcinoma trials with a reported enrollment target (57% lower).
The record links to 10 conditions, with Head and Neck Carcinoma appearing as the primary indexed condition, and to 5 interventions - of which Computed Tomography is the first listed.
NCT05075980 lists 9 locations in 4 states (Minnesota, Arizona, Wisconsin).
Frequently Asked Questions
What is clinical trial NCT05075980 about?
NCT05075980 is a clinical study titled "Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study". This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radia...
What is the current status of trial NCT05075980?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 174 participants. The study started on 2022-02-16. Estimated completion is 2035-11-15.
What conditions does trial NCT05075980 study?
This clinical trial studies the following conditions: Head and Neck Carcinoma, Oropharyngeal Carcinoma, Head and Neck Carcinoma of Unknown Primary, Oral Cavity Carcinoma, Metastatic Malignant Neoplasm in the Lymph Nodes.
What interventions are being tested in trial NCT05075980?
The interventions under investigation include: Computed Tomography (PROCEDURE), Cisplatin (DRUG), Quality-of-Life Assessment (OTHER), Questionnaire Administration (OTHER), Intensity-Modulated Proton Therapy (PROCEDURE).
Who is sponsoring clinical trial NCT05075980?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05075980 being conducted?
This trial has 9 study locations across Arizona, Florida, Minnesota, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Head and Neck Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05075980's enrollment target sits among peer trials
174 9th of 30 higher than 22 of 30 other Head and Neck Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Head and Neck Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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