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ClinicalTrials.gov 14 recruiting now official registry

Glioma, Malignant clinical trials

14 of 20 indexed Glioma, Malignant trials are currently recruiting.

20 US clinical trials · 14 currently recruiting

Glioma, Malignant is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Nader Sanai, running 3 of these trials.

The research picture

Glioma, Malignant has 20 registered US clinical trials, 14 of them open to new participants right now, about 70% of the total.

14
recruiting participants now
70%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: Nader Sanai
Phase 115Phase 31

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 3 432 participants

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Northwell Health

NCT05271240

RECRUITING Phase 1 191 participants

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Tango Therapeutics

NCT06810544

RECRUITING Phase 1 90 participants

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

Darell Bigner

NCT04547777

RECRUITING Phase 1 56 participants

Imaging of Solid Tumors Using 18F-TRX

Rahul Aggarwal

NCT06942104

RECRUITING Phase 1 34 participants

Safety and Tolerability of Fb-PMT in Recurrent Glioblastoma

NanoPharmaceuticals

NCT05226494

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING Early Phase 1 30 participants

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

Children's Hospital of Philadelphia

NCT05555550

RECRUITING Early Phase 1 30 participants

18F-Fluciclovine PET-MRI in High-grade Glioma

Children's Hospital of Philadelphia

NCT05553041

RECRUITING NA 28 participants

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

Baptist Health South Florida

NCT06397560

RECRUITING Early Phase 1 20 participants

Window of Opportunity Study of DSP-0390 in Gliomas

Washington University School of Medicine

NCT06636162

RECRUITING Phase 1 20 participants

Repeated Neural Stem Cell Based Virotherapy for Newly Diagnosed High Grade Glioma

Northwestern University

NCT06169280

RECRUITING Phase 1 18 participants

CUE-102 in Recurrent Glioblastoma

David Reardon, MD

NCT06917885

RECRUITING Early Phase 1 12 participants

Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG

Nader Sanai

NCT05773326

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

ACTIVE NOT RECRUITING Early Phase 1 97 participants

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Nader Sanai

NCT05182905

ACTIVE NOT RECRUITING Early Phase 1 42 participants

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

Nader Sanai

NCT05076513

ACTIVE NOT RECRUITING Phase 1 24 participants

ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM

Mustafa Khasraw, MBChB, MD, FRCP, FRACP

NCT05283109

ACTIVE NOT RECRUITING Early Phase 1 16 participants

Niraparib In Recurrent IDH 1/2 Gliomas

Massachusetts General Hospital

NCT05406700

COMPLETED NA 13 participants

Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

Washington University School of Medicine

NCT05393258

COMPLETED Phase 1 12 participants

Effect of Perampanel on Peritumoral Hyperexcitability in HGG

Dana-Farber Cancer Institute

NCT04497142

Phase Distribution

PhaseTrial count
Phase 1 15
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioma, Malignant Trial Landscape

20 indexed Glioma, Malignant studies · 14 recruiting (70%).

Phase mix: 1 late (III/IV) vs 15 early (I/II).

Top sponsor: Nader Sanai (3 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioma, Malignant?

PlainTrial tracks 20 US clinical trials for Glioma, Malignant, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioma, Malignant?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.