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COMPLETED Phase 2

Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)

NCT00093964 · View on ClinicalTrials.gov ↗

Study Summary

This study will investigate clinical activity, safety, and tolerability of the anti-angiogenic compound cilengitide (EMD 121974) in the treatment of first recurrence of glioblastoma multiforme (GBM).

Conditions Studied

Interventions

  • DRUG Cilengitide 500 mg
  • DRUG Cilengitide 2000 mg

Study Locations (17)

Massachusetts

  • Massachusetts General Hospital — Boston
  • University of Massachusetts — Worcester

Texas

  • Baylor University Medical Center at Dallas — Dallas
  • University of Texas MD Anderson Cancer Center — Houston

Alabama

  • University of Alabama at Birmingham — Birmingham

Arizona

  • Barrow Neurological Institute — Phoenix

California

  • UCLA Medical Center — Los Angeles

Colorado

  • Denise Damek — Aurora

Illinois

  • Northwestern University — Chicago

Indiana

  • Indiana University Medical Center — Indianapolis

Trial Details

FieldValue
Enrollment Target 81 participants
Start Date 2004-10-13
Est. Completion 2010-10-21
Phase Phase 2

Sponsor

EMD Serono

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00093964

The ClinicalTrials.gov registry entry for NCT00093964 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 81 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is EMD Serono, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Glioblastoma Multiforme appearing as the primary indexed condition, and to 2 interventions — of which Cilengitide 500 mg is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00093964 reports 17 study locations spanning 15 distinct geographic areas — top geographies include Massachusetts, Texas, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00093964 about?

NCT00093964 is a clinical study titled "Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)". This study will investigate clinical activity, safety, and tolerability of the anti-angiogenic compound cilengitide (EMD 121974) in the treatment of first recurrence of glioblastoma multiforme (GBM).

What is the current status of trial NCT00093964?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 81 participants. The study started on 2004-10-13. Estimated completion is 2010-10-21.

What conditions does trial NCT00093964 study?

This clinical trial studies the following conditions: Glioblastoma Multiforme. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00093964?

The interventions under investigation include: Cilengitide 500 mg (DRUG), Cilengitide 2000 mg (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00093964?

This trial is sponsored by EMD Serono, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00093964 being conducted?

This trial has 17 study locations across Alabama, Arizona, California, Colorado, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial