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ACTIVE NOT RECRUITING

Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients

NCT06054529 · View on ClinicalTrials.gov ↗

Study Summary

To learn how altered metabolism in GBM causes tumor growth and resistance to drug therapy. In this pilot research study, we will dose GBM patients with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We will measure how fast the nicotinamide is converted to methyl nicotinamide. We believe that the speed of this chemical reaction in the tumor (fast versus slow) may be correlated with GBM aggressiveness

Conditions Studied

Interventions

  • PROCEDURE Surgical removal of the GBM tumor
  • OTHER d4-NAM infusion

Study Locations (1)

Florida

  • AdventHealth Translational Research Institute — Orlando

Trial Details

FieldValue
Enrollment Target 2 participants
Start Date 2023-09-11
Est. Completion 2025-12

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06054529

The ClinicalTrials.gov registry entry for NCT06054529 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AdventHealth Translational Research Institute, which has 35 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Glioblastoma Multiforme appearing as the primary indexed condition, and to 2 interventions — of which Surgical removal of the GBM tumor is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06054529 reports 1 study location spanning 1 distinct geographic area — top geographies include Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06054529 about?

NCT06054529 is a clinical study titled "Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients". To learn how altered metabolism in GBM causes tumor growth and resistance to drug therapy. In this pilot research study, we will dose GBM patients with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We wil...

What is the current status of trial NCT06054529?

This trial is currently active not recruiting. The enrollment target is 2 participants. The study started on 2023-09-11. Estimated completion is 2025-12.

What conditions does trial NCT06054529 study?

This clinical trial studies the following conditions: Glioblastoma Multiforme. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06054529?

The interventions under investigation include: Surgical removal of the GBM tumor (PROCEDURE), d4-NAM infusion (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06054529?

This trial is sponsored by AdventHealth Translational Research Institute, which has 35 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06054529 being conducted?

This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial