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NCT06054529 · ClinicalTrials.gov registry record

Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients

A clinical trial of Glioblastoma Multiforme, sponsored by AdventHealth Translational Research Institute.

Active
Registry status
2
Enrollment target
1
Study location

NCT06054529: Active study of Glioblastoma Multiforme, sponsored by AdventHealth Translational Research Institute.

NCT06054529 is a study of Glioblastoma Multiforme that is active but no longer recruiting, run by AdventHealth Translational Research Institute. The registered enrollment target is 2 participants, below the 97-participant average among 88 other Glioblastoma Multiforme trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06054529, a study of Glioblastoma Multiforme, is active but no longer recruiting, sponsored by AdventHealth Translational Research Institute.

ACTIVE NOT RECRUITING
Registry status
2 participants
Enrollment target
1
Study location

Study Summary

To learn how altered metabolism in GBM causes tumor growth and resistance to drug therapy. In this pilot research study, we will dose GBM patients with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We will measure how fast the nicotinamide is converted to methyl nicotinamide. We believe that the speed of this chemical reaction in the tumor (fast versus slow) may be correlated with GBM aggressiveness

Primary Outcome

Resected tumor tissue will undergo routine testing

Conditions Studied

Glioblastoma Multiforme

Interventions

  • PROCEDURE Surgical removal of the GBM tumor
  • OTHER d4-NAM infusion

Study Locations (1)

Florida

  • AdventHealth Translational Research Institute - Orlando

Trial Details

FieldValue
Enrollment Target 2 participants
Start Date 2023-09-11
Est. Completion 2025-12
AdventHealth Translational Research Institute

54 total trials

What the registry record for NCT06054529 still lists

NCT06054529 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 97-participant average among 88 other Glioblastoma Multiforme trials with a reported enrollment target (98% lower).

The record links to 1 condition, with Glioblastoma Multiforme appearing as the primary indexed condition, and to 2 interventions - of which Surgical removal of the GBM tumor is the first listed.

NCT06054529 reports a single indexed study location in Florida.

Frequently Asked Questions

What is clinical trial NCT06054529 about?

NCT06054529 is a clinical study titled "Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients". To learn how altered metabolism in GBM causes tumor growth and resistance to drug therapy. In this pilot research study, we will dose GBM patients with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We wil...

What is the current status of trial NCT06054529?

This trial is currently active not recruiting. The enrollment target is 2 participants. The study started on 2023-09-11. Estimated completion is 2025-12.

What conditions does trial NCT06054529 study?

This clinical trial studies the following conditions: Glioblastoma Multiforme.

What interventions are being tested in trial NCT06054529?

The interventions under investigation include: Surgical removal of the GBM tumor (PROCEDURE), d4-NAM infusion (OTHER).

Who is sponsoring clinical trial NCT06054529?

This trial is sponsored by AdventHealth Translational Research Institute, which has 54 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06054529 being conducted?

This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Glioblastoma Multiforme

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06054529's enrollment target sits among peer trials

2 89th of 88 the lowest of 88 other Glioblastoma Multiforme trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Glioblastoma Multiforme trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT06054529, the US trial registry maintained by the National Library of Medicine. NCT06054529 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.