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Glaucoma clinical trials
39 of 94 indexed Glaucoma trials are currently recruiting.
94 US clinical trials · 39 currently recruiting
Glaucoma is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is Stanford University, running 8 of these trials.
The research picture
Glaucoma has 94 registered US clinical trials, 39 of them open to new participants right now, about 41% of the total.
- 39
- recruiting participants now
- 41%
- of trials open to enrollment
- 16
- in Phase 3–4 (later-stage)
- 8
- top sponsor: Stanford University
Active & Recent Trials
94 total, page 2 of 2
Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy
Alcon Research
NCT00444665
Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients
Laboratoires Thea
NCT05397600
Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt
Bausch & Lomb Incorporated
NCT03896633
Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension
Allergan
NCT00652106
Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension
Novartis Pharmaceuticals
NCT00846989
Bimatoprost 0.03% Versus Travoprost 0.004% in Patients Currently on Latanoprost 0.005%
Allergan
NCT00440011
Primary Tube Versus Trabeculectomy Study
University of Miami
NCT00666237
Pigment Dispersion Syndrome With and Without Glaucoma
National Eye Institute (NEI)
NCT00001152
Chart Review of XEN 45 Gel Stent: Long Term Performance and Safety Assessment (XEN LT)
Allergan
NCT03868254
Will Listening to Music Make it Easier to Take a Visual Field Test?
Wills Eye
NCT01027039
A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma
Inotek Pharmaceuticals Corporation
NCT01123785
Macular Ganglion Cell Analysis (GCA) of the Cirrus HD-OCT in Glaucoma
Carl Zeiss Meditec
NCT01272102
Ahmed Glaucoma Valve Surgery With Mitomycin-C
University of California, San Francisco
NCT02805257
A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension
Allergan
NCT01863953
The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program
University of Michigan
NCT03159247
Testing Latest Version of NidekRS3000Adv
Doheny Image Reading Center
NCT03318705
Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy
Lahey Clinic
NCT00695747
Steroid Eyedrop Adherence After Trabeculectomy
Johns Hopkins University
NCT03402802
Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma
Amakem
NCT01693315
Baerveldt 350 vs Ahmed ClearPath 250 for the Treatment of Glaucoma
State University of New York at Buffalo
NCT04542616
AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure
Alcon Research
NCT01484951
Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma
Dompé Farmaceutici S.p.A
NCT02855450
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
Ohio State University
NCT04412096
How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?
Wills Eye
NCT00798694
SDOCT-GMPE Software
Duke University
NCT02235454
A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
Mati Therapeutics
NCT01481051
Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data
Indiana University
NCT01145898
Topcon 3D OCT-1000 Optical Coherence Tomography System
Topcon Medical Systems
NCT00792259
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).
Hoffmann-La Roche
NCT02622334
Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients
University of Colorado, Denver
NCT00454922
Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)
Cornerstone Health Care, PA
NCT02167035
Comparing the Effect of the Water Drinking Test on Intraocular Pressure
Wills Eye
NCT02001155
Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow
Indiana University
NCT01308788
Circadian Rhythms of Aqueous Humor Dynamics in Humans
University of Nebraska
NCT00572936
Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects
University of Wisconsin, Madison
NCT01864642
Lucentis Versus Mitomycin C During Glaucoma Surgery
Wills Eye
NCT00626782
The Effects of the Water Drinking Test on Intraocular Pressure
University of California, San Diego
NCT01507584
Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Massachusetts Eye and Ear Infirmary
NCT00824824
An App-based Instructional Platform to Improve Eye Drop Recall
University of California, San Francisco
NCT06045390
A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma
NYU Langone Health
NCT03188042
Does Oral Acetaminophen Lower Intraocular Pressure?
Johns Hopkins University
NCT02366065
Retinal Effects of Balance Goggles System in Glaucoma Balance Goggles System (BGS) in Patients With Glaucoma
Stanford University
NCT04035239
Adult Providing Access to the Visual Environment (PAVE) - Glaucoma Pilot
Vanderbilt University
NCT00338208
Efficacy of Bimatoprost 0.03% in Patients Who Are Low-Responders to Latanoprost
Innovative Medical
NCT00347841
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 10 |
| Phase 3 | 5 |
| Phase 4 | 11 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Glaucoma Trial Landscape
94 indexed Glaucoma studies · 39 recruiting (41%).
Phase mix: 16 late (III/IV) vs 21 early (I/II).
Top sponsor: Stanford University (8 trials), 9 others listed. 44 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Glaucoma?
PlainTrial tracks 94 US clinical trials for Glaucoma, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Glaucoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.