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ClinicalTrials.gov 39 recruiting now official registry

Glaucoma clinical trials

39 of 94 indexed Glaucoma trials are currently recruiting.

94 US clinical trials · 39 currently recruiting

Glaucoma is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is Stanford University, running 8 of these trials.

The research picture

Glaucoma has 94 registered US clinical trials, 39 of them open to new participants right now, about 41% of the total.

39
recruiting participants now
41%
of trials open to enrollment
16
in Phase 3–4 (later-stage)
8
top sponsor: Stanford University
Phase 111Phase 210Phase 35Phase 411

Active & Recent Trials

94 total, page 2 of 2

COMPLETED Phase 4 750 participants

Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy

Alcon Research

NCT00444665

COMPLETED Phase 3 684 participants

Efficacy and Safety Assessment of T4032 (Unpreserved Bimatoprost 0.01%) Versus Lumigan® 0.01% in Ocular Hypertensive or Glaucomatous Patients

Laboratoires Thea

NCT05397600

COMPLETED Phase 1 637 participants

Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt

Bausch & Lomb Incorporated

NCT03896633

COMPLETED Phase 3 432 participants

Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension

Allergan

NCT00652106

COMPLETED Phase 1 276 participants

Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension

Novartis Pharmaceuticals

NCT00846989

COMPLETED Phase 4 266 participants

Bimatoprost 0.03% Versus Travoprost 0.004% in Patients Currently on Latanoprost 0.005%

Allergan

NCT00440011

COMPLETED Phase 4 242 participants

Primary Tube Versus Trabeculectomy Study

University of Miami

NCT00666237

COMPLETED 175 participants

Pigment Dispersion Syndrome With and Without Glaucoma

National Eye Institute (NEI)

NCT00001152

COMPLETED 174 participants

Chart Review of XEN 45 Gel Stent: Long Term Performance and Safety Assessment (XEN LT)

Allergan

NCT03868254

COMPLETED 160 participants

Will Listening to Music Make it Easier to Take a Visual Field Test?

Wills Eye

NCT01027039

COMPLETED Phase 1 144 participants

A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma

Inotek Pharmaceuticals Corporation

NCT01123785

COMPLETED 119 participants

Macular Ganglion Cell Analysis (GCA) of the Cirrus HD-OCT in Glaucoma

Carl Zeiss Meditec

NCT01272102

COMPLETED Phase 2 119 participants

Ahmed Glaucoma Valve Surgery With Mitomycin-C

University of California, San Francisco

NCT02805257

COMPLETED Phase 2 112 participants

A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension

Allergan

NCT01863953

COMPLETED NA 107 participants

The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program

University of Michigan

NCT03159247

COMPLETED 100 participants

Testing Latest Version of NidekRS3000Adv

Doheny Image Reading Center

NCT03318705

COMPLETED NA 95 participants

Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy

Lahey Clinic

NCT00695747

COMPLETED 92 participants

Steroid Eyedrop Adherence After Trabeculectomy

Johns Hopkins University

NCT03402802

COMPLETED Phase 2 82 participants

Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma

Amakem

NCT01693315

COMPLETED NA 80 participants

Baerveldt 350 vs Ahmed ClearPath 250 for the Treatment of Glaucoma

State University of New York at Buffalo

NCT04542616

COMPLETED Phase 4 74 participants

AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure

Alcon Research

NCT01484951

COMPLETED Phase 1 60 participants

Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma

Dompé Farmaceutici S.p.A

NCT02855450

COMPLETED Phase 4 59 participants

Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance

Ohio State University

NCT04412096

COMPLETED Phase 4 58 participants

How Similar Are Changes to the Surface of the Eye When Two Different Glaucoma Eye Drops Are Used?

Wills Eye

NCT00798694

COMPLETED NA 57 participants

SDOCT-GMPE Software

Duke University

NCT02235454

COMPLETED Phase 2 57 participants

A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics

NCT01481051

COMPLETED 56 participants

Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data

Indiana University

NCT01145898

COMPLETED 48 participants

Topcon 3D OCT-1000 Optical Coherence Tomography System

Topcon Medical Systems

NCT00792259

COMPLETED Phase 1 45 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).

Hoffmann-La Roche

NCT02622334

COMPLETED NA 44 participants

Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients

University of Colorado, Denver

NCT00454922

COMPLETED Phase 4 43 participants

Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)

Cornerstone Health Care, PA

NCT02167035

COMPLETED 40 participants

Comparing the Effect of the Water Drinking Test on Intraocular Pressure

Wills Eye

NCT02001155

COMPLETED 35 participants

Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow

Indiana University

NCT01308788

COMPLETED Phase 2 30 participants

Circadian Rhythms of Aqueous Humor Dynamics in Humans

University of Nebraska

NCT00572936

COMPLETED NA 28 participants

Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects

University of Wisconsin, Madison

NCT01864642

COMPLETED Phase 2 24 participants

Lucentis Versus Mitomycin C During Glaucoma Surgery

Wills Eye

NCT00626782

COMPLETED NA 23 participants

The Effects of the Water Drinking Test on Intraocular Pressure

University of California, San Diego

NCT01507584

COMPLETED NA 21 participants

Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)

Massachusetts Eye and Ear Infirmary

NCT00824824

COMPLETED NA 20 participants

An App-based Instructional Platform to Improve Eye Drop Recall

University of California, San Francisco

NCT06045390

COMPLETED NA 18 participants

A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma

NYU Langone Health

NCT03188042

COMPLETED Early Phase 1 11 participants

Does Oral Acetaminophen Lower Intraocular Pressure?

Johns Hopkins University

NCT02366065

COMPLETED Phase 1 11 participants

Retinal Effects of Balance Goggles System in Glaucoma Balance Goggles System (BGS) in Patients With Glaucoma

Stanford University

NCT04035239

COMPLETED NA 2 participants

Adult Providing Access to the Visual Environment (PAVE) - Glaucoma Pilot

Vanderbilt University

NCT00338208

COMPLETED Phase 4

Efficacy of Bimatoprost 0.03% in Patients Who Are Low-Responders to Latanoprost

Innovative Medical

NCT00347841

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 10
Phase 3 5
Phase 4 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glaucoma Trial Landscape

94 indexed Glaucoma studies · 39 recruiting (41%).

Phase mix: 16 late (III/IV) vs 21 early (I/II).

Top sponsor: Stanford University (8 trials), 9 others listed. 44 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glaucoma?

PlainTrial tracks 94 US clinical trials for Glaucoma, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glaucoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.