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Retinal Blood Flow and Autoregulation
NCT05344274 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Indocyanine Green Angiography
- BIOLOGICAL Isocapnic Oxygen
- DIAGNOSTIC_TEST Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO)
Study Locations (4)
Maryland
- University of Maryland Faculty Physicians, Inc — Baltimore
- University of Maryland Medical Center — Baltimore
- University of Maryland, Baltimore — Baltimore
- Food and Drug Administration (FDA) — Silver Spring
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2022-05-23 |
| Est. Completion | 2027-09 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05344274
The ClinicalTrials.gov registry entry for NCT05344274 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Maryland, Baltimore, which has 559 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Glaucoma appearing as the primary indexed condition, and to 3 interventions — of which Indocyanine Green Angiography is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05344274 reports 4 study locations spanning 1 distinct geographic area — top geographies include Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05344274 about?
NCT05344274 is a clinical study titled "Retinal Blood Flow and Autoregulation". The purpose of this study is to establish autoregulation of retinal blood flow in arterioles and capillaries as a biomarker for early primary open angle glaucoma.
What is the current status of trial NCT05344274?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 90 participants. The study started on 2022-05-23. Estimated completion is 2027-09.
What conditions does trial NCT05344274 study?
This clinical trial studies the following conditions: Glaucoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05344274?
The interventions under investigation include: Indocyanine Green Angiography (DIAGNOSTIC_TEST), Isocapnic Oxygen (BIOLOGICAL), Ocular Imaging with Optical Coherence Tomography (OCT) and Adaptive Optics (AO) (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05344274?
This trial is sponsored by University of Maryland, Baltimore, which has 559 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05344274 being conducted?
This trial has 4 study locations across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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