Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06289491 · ClinicalTrials.gov registry record · NA
A Trial of Hydrus Microstent Versus Goniotomy
A NA study of Glaucoma and Glaucoma Open-Angle, sponsored by Massachusetts Eye and Ear Infirmary.
- Recruiting
- Registry status
- NA
- Development phase
- 243
- Enrollment target
- 1
- Study location
NCT06289491: Recruiting NA study of Glaucoma and Glaucoma Open-Angle, sponsored by Massachusetts Eye and Ear Infirmary.
NCT06289491 is a NA study of Glaucoma and Glaucoma Open-Angle that is actively recruiting participants, run by Massachusetts Eye and Ear Infirmary. The registered enrollment target is 243 participants, below the 908-participant average among 92 other Glaucoma trials with a reported enrollment target (73% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06289491, a NA study of Glaucoma and Glaucoma Open-Angle, is actively recruiting participants, sponsored by Massachusetts Eye and Ear Infirmary.
- RECRUITING
- Registry status
- NA
- Development phase
- 243 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate open-angle glaucoma. The main questions it aims to answer are: * How do the intraocular pressure lowering effects of these three microinvasive glaucoma surgeries compare? * How do the safety profiles of these three microinvasive glaucoma surgeries compare? Participants will be randomized to one of these three microinvasive glaucoma surgeries in combination with cataract surgery.
Conditions Studied
Interventions
- PROCEDURE Hydrus Microstent
- PROCEDURE Incisional goniotomy
- PROCEDURE Excisional goniotomy
Study Locations (1)
Massachusetts
- Massachusetts Eye and Ear - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 243 participants |
| Start Date | 2025-02-14 |
| Est. Completion | 2029-04 |
| Phase | NA |
What NCT06289491 shows while recruiting
NCT06289491 is an interventional study that assigns participants to a tested intervention. The registered 243 participants enrollment target is mid-sized for trials with a published cap, below the 908-participant average among 92 other Glaucoma trials with a reported enrollment target (73% lower).
The record links to 2 conditions, with Glaucoma appearing as the primary indexed condition, and to 3 interventions - of which Hydrus Microstent is the first listed.
NCT06289491 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06289491 about?
NCT06289491 is a clinical study titled "A Trial of Hydrus Microstent Versus Goniotomy". The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate open-angle glaucoma. The main questions it aims to answer are: * How do the ...
What is the current status of trial NCT06289491?
This trial is currently recruiting. It is a NA study. The enrollment target is 243 participants. The study started on 2025-02-14. Estimated completion is 2029-04.
What conditions does trial NCT06289491 study?
This clinical trial studies the following conditions: Glaucoma, Glaucoma Open-Angle.
What interventions are being tested in trial NCT06289491?
The interventions under investigation include: Hydrus Microstent (PROCEDURE), Incisional goniotomy (PROCEDURE), Excisional goniotomy (PROCEDURE).
Who is sponsoring clinical trial NCT06289491?
This trial is sponsored by Massachusetts Eye and Ear Infirmary, which has 73 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06289491 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glaucoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06289491's enrollment target sits among peer trials
243 22nd of 92 higher than 71 of 92 other Glaucoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glaucoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Village-Integrated Eye Worker Trial II
RECRUITING · NA
-
Tolerability of an Anesthesia-free Tonometer Tip
RECRUITING · NA
-
Electrical Stimulation for the Treatment of Optic Neuropathies
RECRUITING · NA
-
The Role of Music in Enhancing Attention During Visual Field Exams for Pediatric Glaucoma Patients
RECRUITING · NA
-
Electrical Stimulation for the Treatment of Glaucoma
RECRUITING · NA
-
Hyperbaric Oxygen Therapy for Optic Neuropathies
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06253871 · 243 participants · Phase 1
A Phase 1/1b Study of IAM1363 in HER2 Cancers
- NCT06536296 · 243 participants · NA
The Impact of Music Medicine on Preterm Brain Development and Behavior
- NCT06907615 · 243 participants · Phase 2
A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
- NCT02227251 · 244 participants · Phase 2
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI