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NCT06993597 · ClinicalTrials.gov registry record
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
A clinical trial of Glaucoma, sponsored by University of Maryland, Baltimore.
- Recruiting
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT06993597: Recruiting study of Glaucoma, sponsored by University of Maryland, Baltimore.
NCT06993597 is a study of Glaucoma that is actively recruiting participants, run by University of Maryland, Baltimore. The registered enrollment target is 60 participants, below the 910-participant average among 92 other Glaucoma trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06993597, a study of Glaucoma, is actively recruiting participants, sponsored by University of Maryland, Baltimore.
- RECRUITING
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to assess changes in corneal biomechanics following intraocular pressure (IOP)-lowering treatment. The goal is to determine whether Brillouin-derived biomechanical measurements can serve as biomarkers for glaucoma risk and progression.
Primary Outcome
Brillouin microscopy will be used to measure the corneal modulus of elasticity. The primary outcome is the change in corneal stiffness (Brillouin shift in MHz) across time points in subjects treated with prostaglandin analogs versus beta blockers, and between groups at baseline (NTG, HTG, controls).
Conditions Studied
Interventions
- DRUG Prostaglandin Analogue -Containing IOP-Lowering Therapy
- DRUG Beta Blocker
- DEVICE Brillouin Microscopy
Study Locations (1)
Maryland
- University of Maryland School of Medicine - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2026-06 |
What NCT06993597 shows while recruiting
NCT06993597 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 910-participant average among 92 other Glaucoma trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Glaucoma appearing as the primary indexed condition, and to 3 interventions - of which Prostaglandin Analogue -Containing IOP-Lowering Therapy is the first listed.
NCT06993597 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06993597 about?
NCT06993597 is a clinical study titled "Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy". This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to asses...
What is the current status of trial NCT06993597?
This trial is currently recruiting. The enrollment target is 60 participants. The study started on 2025-09-01. Estimated completion is 2026-06.
What conditions does trial NCT06993597 study?
This clinical trial studies the following conditions: Glaucoma.
What interventions are being tested in trial NCT06993597?
The interventions under investigation include: Prostaglandin Analogue -Containing IOP-Lowering Therapy (DRUG), Beta Blocker (DRUG), Brillouin Microscopy (DEVICE).
Who is sponsoring clinical trial NCT06993597?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06993597 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glaucoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06993597's enrollment target sits among peer trials
60 53rd of 92 higher than 35 of 92 other Glaucoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glaucoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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