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ClinicalTrials.gov 13 recruiting now official registry

Geographic Atrophy clinical trials

13 of 28 indexed Geographic Atrophy trials are currently recruiting.

28 US clinical trials · 13 currently recruiting

Geographic Atrophy is the subject of 28 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Perceive Biotherapeutics, running 2 of these trials.

The research picture

Geographic Atrophy has 28 registered US clinical trials, 13 of them open to new participants right now, about 46% of the total.

13
recruiting participants now
46%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: Perceive Biotherapeutics
Phase 18Phase 29Phase 33

Active & Recent Trials

28 total, page 1 of 1

RECRUITING 1,000 participants

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Astellas Pharma Global Development

NCT06779773

RECRUITING 600 participants

High Resolution Retinal Imaging

University of Pennsylvania

NCT01866371

RECRUITING Phase 2 274 participants

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Janssen Research & Development

NCT06635148

RECRUITING Phase 1 132 participants

A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Hoffmann-La Roche

NCT06961370

RECRUITING NA 125 participants

Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD

VisionCare

NCT05438732

RECRUITING Phase 1 104 participants

A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

Sanofi

NCT07215234

RECRUITING Phase 2 70 participants

SGLT2 Inhibitors in Geographic Atrophy

Washington University School of Medicine

NCT07174687

RECRUITING Phase 1 66 participants

Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

AbbVie

NCT07160179

RECRUITING Phase 2 60 participants

A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

Genentech

NCT05626114

RECRUITING Phase 1 60 participants

Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Perceive Biotherapeutics

NCT06087458

RECRUITING 30 participants

A Prospective Observational Study to Assess the Reliability and Validity of the MLSDT

Nanoscope Therapeutics

NCT06805474

RECRUITING Phase 2 24 participants

A Phase IIb Randomized, Multicenter Trial of Subretinal CPCB-RPE1 in Advanced Dry AMD (Geographic Atrophy)

Regenerative Patch Technologies

NCT06557460

RECRUITING Phase 1 20 participants

Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

National Eye Institute (NEI)

NCT04339764

ACTIVE NOT RECRUITING Phase 3 659 participants

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Geographic Atrophy (GA)

Annexon

NCT06510816

ACTIVE NOT RECRUITING Phase 3 429 participants

Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy

Belite Bio

NCT05949593

ACTIVE NOT RECRUITING 300 participants

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Apellis Pharmaceuticals

NCT06161584

ACTIVE NOT RECRUITING 250 participants

Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study

Complement Therapeutics

NCT05797896

ACTIVE NOT RECRUITING Phase 2 202 participants

A Study to Test Whether BI 771716 Helps People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

Boehringer Ingelheim

NCT06722157

ACTIVE NOT RECRUITING Phase 2 150 participants

A Study to Test Different Doses of BI 1584862 in People With a Distinct Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

Boehringer Ingelheim

NCT06769048

ACTIVE NOT RECRUITING Phase 1 60 participants

Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy

Ocugen

NCT06018558

ACTIVE NOT RECRUITING Phase 1 45 participants

Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Perceive Biotherapeutics

NCT05380492

ACTIVE NOT RECRUITING Phase 1 30 participants

Evaluation of Kamuvudine-8 in Subjects With Geographic Atrophy

Michelle Abou-Jaoude

NCT06164587

COMPLETED Phase 3 621 participants

Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

Apellis Pharmaceuticals

NCT03525600

COMPLETED Phase 2 270 participants

A Study Investigating the Efficacy and Safety of Intravitreal Injections of ANX007 in Patients With Geographic Atrophy

Annexon

NCT04656561

COMPLETED Phase 2 200 participants

Phase 2/3 Study of ALK-001 in Geographic Atrophy

Alkeus Pharmaceuticals

NCT03845582

COMPLETED Phase 2 96 participants

A Study of Lampalizumab Intravitreal Injections Administered Every Two Weeks or Every Four Weeks to Participants With Geographic Atrophy

Genentech

NCT02288559

COMPLETED 85 participants

Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)

Carl Zeiss Meditec

NCT01272076

COMPLETED 32 participants

Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO

Optos

NCT01692938

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 9
Phase 3 3

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Geographic Atrophy Trial Landscape

28 indexed Geographic Atrophy studies · 13 recruiting (46%).

Phase mix: 3 late (III/IV) vs 17 early (I/II).

Top sponsor: Perceive Biotherapeutics (2 trials), 9 others listed. 28 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Geographic Atrophy?

PlainTrial tracks 28 US clinical trials for Geographic Atrophy, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Geographic Atrophy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.