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NCT06018558 · ClinicalTrials.gov registry record · Phase 1

Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy

A Phase 1 study of Geographic Atrophy, sponsored by Ocugen.

Active
Registry status
Phase 1
Development phase
60
Enrollment target
12
Study locations

NCT06018558: Active Phase 1 study of Geographic Atrophy, sponsored by Ocugen.

NCT06018558 is a Phase 1 study of Geographic Atrophy that is active but no longer recruiting, run by Ocugen. The registered enrollment target is 60 participants, below the 220-participant average among 27 other Geographic Atrophy trials with a reported enrollment target (73% lower). The trial reports 12 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06018558, a Phase 1 study of Geographic Atrophy, is active but no longer recruiting, sponsored by Ocugen.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
60 participants
Enrollment target
12
Study locations

Study Summary

This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration (AMD). This is a multicenter study, which will be conducted in two phases and will enroll up to a total of 60 subjects.

Primary Outcome

The primary endpoint is safety, determined by the number of ocular and non-ocular Study Drug-related adverse events (SDAE), treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs).

Conditions Studied

Geographic Atrophy

Interventions

  • GENETIC OCU410

Study Locations (12)

Texas

  • B) Retina Consultants of Texas - Bellaire
  • A) Retina Foundation of the Southwest - Dallas
  • Valley retina Institute - McAllen

Arizona

  • Associated Retina Consultants - Phoenix

Florida

  • Advanced Research, LLC - Coral Springs

Indiana

  • Miidwest Eye Institute - Carmel

Mississippi

  • Mississippi Retina Associates - Jackson

Missouri

  • The Retina Institute - St Louis

New Jersey

  • Mid Atlantic Retina - Cherry Hill

North Carolina

  • Duke Eye Center - Durham

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2023-02-23
Est. Completion 2026-05-29
Phase Phase 1
Ocugen

8 total trials

What the registry record for NCT06018558 still lists

NCT06018558 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 220-participant average among 27 other Geographic Atrophy trials with a reported enrollment target (73% lower).

The record links to 1 condition, with Geographic Atrophy appearing as the primary indexed condition, and to 1 intervention - of which OCU410 is the first listed.

NCT06018558 lists 12 locations in 10 states (Texas, Arizona, Florida).

Frequently Asked Questions

What is clinical trial NCT06018558 about?

NCT06018558 is a clinical study titled "Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy". This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU410 for Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration (AMD). This is a multicenter study, which will be conducted in two phases and will enroll up to a total of 60 subjects.

What is the current status of trial NCT06018558?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2023-02-23. Estimated completion is 2026-05-29.

What conditions does trial NCT06018558 study?

This clinical trial studies the following conditions: Geographic Atrophy.

What interventions are being tested in trial NCT06018558?

The interventions under investigation include: OCU410 (GENETIC).

Who is sponsoring clinical trial NCT06018558?

This trial is sponsored by Ocugen, which has 8 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06018558 being conducted?

This trial has 12 study locations across Arizona, Florida, Indiana, Mississippi, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Geographic Atrophy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06018558's enrollment target sits among peer trials

60 20th of 27 higher than 6 of 27 other Geographic Atrophy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Geographic Atrophy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT06018558, the US trial registry maintained by the National Library of Medicine. NCT06018558 (small enrollment · multi site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.