Apellis Pharmaceuticals

21 total trials 2 currently recruiting 13 completed

Apellis Pharmaceuticals sponsors 21 registered US clinical trials on ClinicalTrials.gov, 2 of them currently recruiting, and 13 completed. 8 of these trials are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Membranoproliferative Glomerulonephritis, with 2 trials.

Trial Pipeline

21 total, page 1 of 1

RECRUITING Phase 2

A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio

NCT07215390

RECRUITING Phase 2

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT04901936

ACTIVE NOT RECRUITING

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

NCT06161584

ACTIVE NOT RECRUITING Phase 3

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

NCT05809531

ACTIVE NOT RECRUITING Phase 2

Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN

NCT04572854

ACTIVE NOT RECRUITING Phase 3

Pegcetacoplan Long Term Safety and Efficacy Extension Study

NCT03531255

COMPLETED Phase 3

Study to Evaluate a Pegcetacoplan (Syfovre®) Prefilled Syringe

NCT07214740

COMPLETED Phase 3

Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

NCT05067127

COMPLETED Phase 3

An Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan (APL-2) in Subjects With Geographic Atrophy Secondary to AMD

NCT04770545

TERMINATED Phase 2

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

NCT04579666

COMPLETED Phase 1

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

NCT04402060

COMPLETED Phase 1

Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophy

NCT03777332

COMPLETED Phase 3

Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

NCT03525600

COMPLETED Phase 3

A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

NCT03525613

COMPLETED Phase 3

Study to Evaluate the Efficacy and Safety of APL-2 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT03500549

COMPLETED Phase 2

Phase II Study Assessing Safety and Efficacy of APL-2 in Glomerulopathies

NCT03453619

TERMINATED Phase 1

Pegcetacoplan (APL-2) in Neovascular AMD

NCT03465709

COMPLETED Phase 2

Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With Warm Type Autoimmune Hemolytic Anemia (wAIHA) or Cold Agglutinin Disease (CAD)

NCT03226678

COMPLETED Phase 2

Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophy

NCT02503332

COMPLETED Phase 1

A Phase I Study to Assess the Safety of Pegcetacoplan (APL-2) as an Add-On to Standard of Care in Subjects With PNH

NCT02264639

COMPLETED Phase 1

Assessment of Safety, Tolerability and Pharmacokinetics of Intravitreal Pegcetacoplan (APL-2) for Patients With Wet AMD

NCT02461771

What the Pipeline for Apellis Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Apellis Pharmaceuticals is linked to 21 US clinical trials across every stage of research activity. Of those, 2 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 13 are already marked complete, representing roughly 62% of the total.

The phase mix for Apellis Pharmaceuticals reports 8 late-stage studies (Phase 3 and Phase 4 combined) and 12 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Apellis Pharmaceuticals is Membranoproliferative Glomerulonephritis with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.