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ACTIVE NOT RECRUITING Phase 3

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Geographic Atrophy (GA)

NCT06510816 · View on ClinicalTrials.gov ↗

Study Summary

The primary purpose of the study is to determine if IVT injections of vonaprument every month reduce vision loss in participants with GA secondary to age-related macular degeneration (AMD).

Conditions Studied

Interventions

  • OTHER Sham Administration
  • DRUG Vonaprument

Study Locations (20)

California

  • Retina-Vitreous Associates Medical Group — Beverly Hills
  • RCOC Clinical Research Institute Inc — Fullerton
  • Global Research Management — Glendale
  • Retina Consultants Medical Group — Modesto
  • Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View
  • Retinal Consultants Medical Group — Sacramento
  • Macula Retina Vitreous Research Institute — Torrance
  • Bay Area Retina Associates — Walnut Creek

Florida

  • Rand Eye Institute — Deerfield Beach
  • National Ophthalmic Research Institute — Fort Myers
  • Florida Retina Institute — Orlando
  • Fort Lauderdale Eye Institute — Plantation
  • Retina Group of Florida — Sarasota
  • Retina Vitreous Associates of Florida — St. Petersburg
  • East Florida Eye Institute — Stuart

Colorado

  • Retina Consultants of Southern Colorado PC — Colorado Springs
  • RSC Research, LLC — Denver

Arizona

  • Retina Macula Institute of Arizona — Scottsdale

Georgia

  • Georgia Retina PC — Marietta

Hawaii

  • Retina Consultants of Hawaii — ‘Aiea

Trial Details

FieldValue
Enrollment Target 659 participants
Start Date 2024-07-30
Est. Completion 2027-10-31
Phase Phase 3

Sponsor

Annexon

35 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06510816

The ClinicalTrials.gov registry entry for NCT06510816 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 659 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Annexon, which has 35 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Geographic Atrophy appearing as the primary indexed condition, and to 2 interventions — of which Sham Administration is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06510816 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Florida, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06510816 about?

NCT06510816 is a clinical study titled "A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Geographic Atrophy (GA)". The primary purpose of the study is to determine if IVT injections of vonaprument every month reduce vision loss in participants with GA secondary to age-related macular degeneration (AMD).

What is the current status of trial NCT06510816?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 659 participants. The study started on 2024-07-30. Estimated completion is 2027-10-31.

What conditions does trial NCT06510816 study?

This clinical trial studies the following conditions: Geographic Atrophy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06510816?

The interventions under investigation include: Sham Administration (OTHER), Vonaprument (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06510816?

This trial is sponsored by Annexon, which has 35 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06510816 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial