Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05797896 · ClinicalTrials.gov registry record
Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study
A clinical trial of Eye Diseases and Geographic Atrophy, sponsored by Complement Therapeutics.
- Active
- Registry status
- 250
- Enrollment target
- 20
- Study locations
NCT05797896: Active study of Eye Diseases and Geographic Atrophy, sponsored by Complement Therapeutics.
NCT05797896 is a study of Eye Diseases and Geographic Atrophy that is active but no longer recruiting, run by Complement Therapeutics. The registered enrollment target is 250 participants, below the 741,294-participant average among 27 other Eye Diseases trials with a reported enrollment target (100% lower). The trial reports 20 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05797896, a study of Eye Diseases and Geographic Atrophy, is active but no longer recruiting, sponsored by Complement Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- 250 participants
- Enrollment target
- 20
- Study locations
Study Summary
An observational study to investigate the natural history and evaluate biomarkers of participants with geographic atrophy secondary to age-related macular degeneration
Primary Outcome
To assess the correlation between circulating levels of complement proteins measured using the Complement Precision Medicine (CPM) Platform and Geographic Atrophy (GA) secondary to Age-related Macular Degeneration (AMD)
Conditions Studied
Study Locations (20)
Other
- Belfast City Hospital - Belfast
- Bradford Royal Infirmary - Bradford
- Frimley Park Hospital - Frimley
- Gloucestershire Royal Hospital - Gloucester
- Liverpool Hospital - Liverpool
- Moorfields Eye Hospital - London
- Western Eye Hospital - London
- Manchester Royal Eye Hospital - Manchester
- Newcastle Hospital - Newcastle
- Nottingham City Hospital - Nottingham
Texas
- Retina Research Institute of Texas - Abilene
- Texas Retina Associates - Plano
- San Antonio Eye Center - San Antonio
California
- Global Research Management - Glendale
- Northern California Retina Vitreous Associates - Mountain View
Indiana
- Midwest Eye Institute - Carmel
Maryland
- Mid Atlantic Retina Specialists - Hagerstown
Nevada
- Sierra Eye Associates - Reno
Oregon
- Verum Research LLC - Eugene
Pennsylvania
- Mid Atlantic Retina - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2023-02-07 |
| Est. Completion | 2027-07-31 |
What the registry record for NCT05797896 still lists
NCT05797896 is an observational study that tracks outcomes without assigning an intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 741,294-participant average among 27 other Eye Diseases trials with a reported enrollment target (100% lower).
The record links to 7 conditions, with Eye Diseases appearing as the primary indexed condition, and to 0 interventions.
NCT05797896 names 20 study sites across 8 states, led by Other, Texas, California.
Frequently Asked Questions
What is clinical trial NCT05797896 about?
NCT05797896 is a clinical study titled "Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study". An observational study to investigate the natural history and evaluate biomarkers of participants with geographic atrophy secondary to age-related macular degeneration
What is the current status of trial NCT05797896?
This trial is currently active not recruiting. The enrollment target is 250 participants. The study started on 2023-02-07. Estimated completion is 2027-07-31.
What conditions does trial NCT05797896 study?
This clinical trial studies the following conditions: Eye Diseases, Geographic Atrophy, Macular Degeneration, Retinal Disease, Retinal Degeneration.
Who is sponsoring clinical trial NCT05797896?
This trial is sponsored by Complement Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05797896 being conducted?
This trial has 20 study locations across California, Indiana, Maryland, Nevada, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Eye Diseases
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05797896's enrollment target sits among peer trials
250 9th of 27 higher than 19 of 27 other Eye Diseases trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Eye Diseases trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Adaptive Optics Retinal Imaging
RECRUITING
-
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
RECRUITING · Phase 3
-
Widefield Confocal Scanning Laser Ophthalmoscope Optimized for Pediatric and Neonatal Imaging
RECRUITING
-
SGLT2 Inhibitors in Geographic Atrophy
RECRUITING · Phase 2
-
Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine (SIGHT) 2
RECRUITING · NA
-
IRIS Registry: Intelligent Research in Sight Registry
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00483249 · 250 participants · NA
Endovascular Exclusion of Thoracoabdominal and/or Paravisceral Abdominal Aortic Aneurysm
- NCT00777712 · 250 participants
Mechanisms Underlying Impaired Diabetic Wound Healing
- NCT01451502 · 250 participants · NA
Infusion of Cell Populations From Unlicensed Umbilical Cord Blood Units
- NCT01771718 · 250 participants
Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI