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A Study of Lampalizumab Intravitreal Injections Administered Every Two Weeks or Every Four Weeks to Participants With Geographic Atrophy
NCT02288559 · View on ClinicalTrials.gov ↗
Study Summary
This multicenter, randomized, single-masked, sham injection-controlled study will investigate the exposure-response and safety of lampalizumab administered intravitreally every 2 weeks (Q2W) or every 4 weeks (Q4W) for 24 weeks in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). A safety run-in assessment will be conducted prior to initiating enrollment in the randomized study.
Conditions Studied
Interventions
- OTHER Sham
- DRUG Lampalizumab
Study Locations (20)
California
- Retinal Diagnostic Center — Campbell
- The Retina Partners — Encino
- Loma Linda University — Loma Linda
- San Diego Retina Associates — Oceanside
- West Coast Retina Medical Group — San Francisco
- California Retina Consultants — Santa Barbara
Florida
- Florida Eye Microsurgical Inst — Boynton Beach
- National Ophthalmic Research Institute — Fort Myers
- Florida Eye Associates — Melbourne
- Retina Care Specialists — Palm Beach Gardens
- Retina Specialty Institute — Pensacola
Arizona
- Barnet Dulaney Perkins Eye Center — Mesa
- University of Arizona; Banner University Medical, Department of Opthalmology — Tucson
Arkansas
- Northwest Arkansas Retina Associates — Springdale
Colorado
- Colorado Retina Associates, PC — Golden
Illinois
- Rush University Medical Center — Chicago
Iowa
- Wolfe Eye Clinic — West Des Moines
Maryland
- Elman Retina Group — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2015-03-30 |
| Est. Completion | 2017-06-02 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02288559
The ClinicalTrials.gov registry entry for NCT02288559 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 96 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Geographic Atrophy appearing as the primary indexed condition, and to 2 interventions — of which Sham is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02288559 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02288559 about?
NCT02288559 is a clinical study titled "A Study of Lampalizumab Intravitreal Injections Administered Every Two Weeks or Every Four Weeks to Participants With Geographic Atrophy". This multicenter, randomized, single-masked, sham injection-controlled study will investigate the exposure-response and safety of lampalizumab administered intravitreally every 2 weeks (Q2W) or every 4 weeks (Q4W) for 24 weeks in participants with geographic atrophy (GA) secondary to age-related mac...
What is the current status of trial NCT02288559?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 96 participants. The study started on 2015-03-30. Estimated completion is 2017-06-02.
What conditions does trial NCT02288559 study?
This clinical trial studies the following conditions: Geographic Atrophy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02288559?
The interventions under investigation include: Sham (OTHER), Lampalizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02288559?
This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02288559 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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