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Generalized Anxiety Disorder: full-pipeline trial registry
18 of 49 indexed Generalized Anxiety Disorder trials are currently recruiting.
Corpus placement: #281 of 28,707 conditions by registered trial count.
49 US clinical trials · 18 currently recruiting · #281 of 28,707 conditions by registered trial count
Generalized Anxiety Disorder: 49 US clinical trials tracked, 18 recruiting.
Generalized Anxiety Disorder is the subject of 49 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 4 of these trials.
Enrollment posture brief
Registry condition generalized-anxiety-disorder
OPEN 18 | RECR 37% | LATE 12 | EARLY 9 | RANK #281 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Prostate Cancer (37% recruiting · 749 trials)
Generalized Anxiety Disorder lists 18 open slots (37% of 49 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Generalized Anxiety Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Generalized Anxiety Disorder is recruiting below its size-band peers.
18 of 49 indexed trials (36.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Generalized Anxiety Disorder trials is spread across many organizations.
Massachusetts General Hospital accounts for 4 of 49 trials (8.2%). 35 distinct sponsors appear on at least one study for this condition label.
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Typical Generalized Anxiety Disorder enrolment sits around 130 participants.
Median target enrolment is 130 among the 49 trials that report a genuine target (sentinel values excluded). 20 of those (40.8%) plan for fewer than 100 participants.
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Generalized Anxiety Disorder research is mostly interventional.
47 interventional and 2 observational studies make up this index (95.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
49 total, page 1 of 1
Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder
Intra-Cellular Therapies
NCT06480383
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
University of Texas at Austin
NCT05467683
Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder
Intra-Cellular Therapies
NCT06701903
Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings
Bradley Hospital
NCT06934525
Brief Smartphone Treatment Study
Penn State University
NCT04846777
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
University of Minnesota
NCT05117255
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
Definium Therapeutics US
NCT06809595
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage)
Definium Therapeutics US
NCT06741228
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Brigham and Women's Hospital
NCT06376734
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
University of Texas at Austin
NCT05427708
MBSR Mechanisms in GAD
NYU Langone Health
NCT05064813
Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety
Baylor College of Medicine
NCT06537128
Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
University of Michigan
NCT06563310
Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
Georgetown University
NCT07028216
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
University of California, Los Angeles
NCT04557891
Massage for GAD: Neuroimaging and Clinical Correlates of Response
University of Utah
NCT06506253
Mindful Self-Compassion for Anxiety Disorders and Depression
Georgetown University
NCT05671419
Use of CBD in the Treatment of Anxiety
University of Florida
NCT06672666
Patient-centered Treatment of Anxiety After Low-Risk Chest Pain in the Emergency Room
Indiana University
NCT04811521
Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
Massachusetts General Hospital
NCT01075672
Brain Stimulation & Generalized Anxiety Study
ProofPilot
NCT04751864
Evaluation of Family-Based Behavioral Treatments for Youth With Anxiety and Obsessive-Compulsive Disorder
Baylor College of Medicine
NCT05967468
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD)
Cybin IRL Limited
NCT06051721
Evaluating the Effects of Stress in Pregnancy
Emory University
NCT00525226
A 10-Week Study for Efficacy and Safety Study of Gabitril in the Treatment of Adults With Generalized Anxiety Disorder
Cephalon
NCT00236067
Safety and Efficacy of Eszopiclone in Patients With Generalized Anxiety Disorder
Sumitomo Pharma America
NCT00235508
Trial to Compare Time to Response in the Symptoms of Anxiety to Concomitant Treatment With Niravam™ and an SSRI or SNRI to Treatment With an SSRI or SNRI Alone in Subjects With Generalized Anxiety Disorder or Panic Disorder
UCB Pharma
NCT00266409
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD
Senseye
NCT05717439
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety
Massachusetts General Hospital
NCT03118752
Study of Pexacerfont (BMS-562086) in the Treatment of Outpatients With Generalized Anxiety Disorder
Bristol-Myers Squibb
NCT00481325
Psychotherapy for Anxiety in Children With Autism Spectrum Disorder
University of South Florida
NCT02028247
Long Term Chamomile Therapy for Anxiety
University of Pennsylvania
NCT01072344
CES for the Treatment of GAD in Young Adults
Electromedical Products International
NCT06124014
Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response
Laureate Institute for Brain Research
NCT02807480
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders
VA Office of Research and Development
NCT01947647
Stress Reduction Techniques and Anxiety: Therapeutic and Neuroendocrine Effects
Massachusetts General Hospital
NCT01033851
Antidepressant Treatment Plus Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Older Adults
Veterans Medical Research Foundation
NCT00601965
Combined Treatment for Generalized Anxiety Disorder (GAD)
University of Pennsylvania
NCT00620776
Efficacy of Extended-release Quetiapine (Seroquel XR) as Adjunctive Therapy to Cognitive Behavioral Therapy in the Treat
Icahn School of Medicine at Mount Sinai
NCT01971203
Chamomile Therapy for Generalized Anxiety
University of Pennsylvania
NCT00645983
A Study of Risperidone Monotherapy in Bipolar Anxiety
University of South Florida
NCT00167479
Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD)
VA Palo Alto Health Care System
NCT01172652
Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli
Georgetown University
NCT03206437
Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
University of South Florida
NCT01178385
Electronic Self-management Resource Training for Mental Health
Case Western Reserve University
NCT01304862
Exercise Training for the Treatment of Generalized Anxiety Disorder
University of Georgia
NCT00953654
Stress Reduction and Anxiety: Effects on the Function and Structure of the Brain
Massachusetts General Hospital
NCT01128309
Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder
University of California, Los Angeles
NCT00674219
An Open-label Study to Investigate the Absorption, Metabolism and Excretion of Radiolabeled PD 0332334 in Six Healthy Male Volunteers
Pfizer
NCT00537615
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 8 |
| Phase 3 | 5 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Generalized Anxiety Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Generalized Anxiety Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Generalized Anxiety Disorder page
49 registered trials, 18 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 18 Generalized Anxiety Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Generalized Anxiety Disorder trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Generalized Anxiety Disorder condition card totals 49 registered trials; most-linked intervention Placebo; top US site state Florida. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.