Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04557891 · ClinicalTrials.gov registry record · NA
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
A NA study of Generalized Anxiety Disorder, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- NA
- Development phase
- 48
- Enrollment target
- 3
- Study locations
NCT04557891: Recruiting NA study of Generalized Anxiety Disorder, sponsored by University of California, Los Angeles.
NCT04557891 is a NA study of Generalized Anxiety Disorder that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 48 participants, below the 214-participant average among 48 other Generalized Anxiety Disorder trials with a reported enrollment target (78% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04557891, a NA study of Generalized Anxiety Disorder, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
- 3
- Study locations
Study Summary
There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygdala. In this double-blind sham-controlled clinical trial, the investigators propose to establish baseline severity of anxiety in 48 patients, then deliver eight treatments over four sessions of focused ultrasound stimulation to the amygdala. Anxiety severity will be assessed using standard psychometric scales after each session, and at follow-ups.
Primary Outcome
HAM-A is a rating scale for measuring the severity of anxiety symptoms.
Conditions Studied
Interventions
- DEVICE Active LIFUP Treatment
- DEVICE Sham LIFUP Treatment
Study Locations (3)
California
- University of California, Los Angeles - Los Angeles
Massachusetts
- Massachusetts General Hospital - Boston
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2021-07-26 |
| Est. Completion | 2027-12 |
| Phase | NA |
What NCT04557891 shows while recruiting
NCT04557891 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 214-participant average among 48 other Generalized Anxiety Disorder trials with a reported enrollment target (78% lower).
The record links to 1 condition, with Generalized Anxiety Disorder appearing as the primary indexed condition, and to 2 interventions - of which Active LIFUP Treatment is the first listed.
NCT04557891 reports a single indexed study location in California, Massachusetts, South Carolina.
Frequently Asked Questions
What is clinical trial NCT04557891 about?
NCT04557891 is a clinical study titled "Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)". There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygdal...
What is the current status of trial NCT04557891?
This trial is currently recruiting. It is a NA study. The enrollment target is 48 participants. The study started on 2021-07-26. Estimated completion is 2027-12.
What conditions does trial NCT04557891 study?
This clinical trial studies the following conditions: Generalized Anxiety Disorder.
What interventions are being tested in trial NCT04557891?
The interventions under investigation include: Active LIFUP Treatment (DEVICE), Sham LIFUP Treatment (DEVICE).
Who is sponsoring clinical trial NCT04557891?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04557891 being conducted?
This trial has 3 study locations across California, Massachusetts, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Generalized Anxiety Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04557891's enrollment target sits among peer trials
48 38th of 48 higher than 11 of 48 other Generalized Anxiety Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Generalized Anxiety Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
RECRUITING · NA
-
Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
RECRUITING · NA
-
Massage for GAD: Neuroimaging and Clinical Correlates of Response
RECRUITING · NA
-
CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
RECRUITING · NA
-
Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
RECRUITING · NA
-
MBSR Mechanisms in GAD
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01765777 · 48 participants · NA
Efficacy of Osteopathic Manipulative Medicine (OMM) and Phototherapy for Patients With Chronic Lower Back Pain
- NCT03073343 · 48 participants · NA
A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
- NCT03431064 · 48 participants
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
- NCT03514602 · 48 participants · NA
Maternal Smoking Cessation and Pediatric Obesity Prevention
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI