Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 12 recruiting now official registry

GBM clinical trials

12 of 25 indexed GBM trials are currently recruiting.

25 US clinical trials · 12 currently recruiting

GBM is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is Northwell Health, running 6 of these trials.

The research picture

GBM has 25 registered US clinical trials, 12 of them open to new participants right now, about 48% of the total.

12
recruiting participants now
48%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
6
top sponsor: Northwell Health
Phase 113Phase 25Phase 33

Active & Recent Trials

25 total, page 1 of 1

RECRUITING Phase 3 450 participants

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Ivy Brain Tumor Center

NCT06388733

RECRUITING Phase 3 432 participants

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Northwell Health

NCT05271240

RECRUITING Phase 1 175 participants

Study of LP-184 in Patients With Advanced Solid Tumors

Lantern Pharma

NCT05933265

RECRUITING Phase 2 162 participants

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Black Diamond Therapeutics

NCT07326566

RECRUITING NA 155 participants

WBSI Guided Personalized Delivery of TTFields

Abramson Cancer Center at Penn Medicine

NCT05086497

RECRUITING Phase 2 103 participants

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

Alpheus Medical

NCT07225621

RECRUITING Phase 1 66 participants

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Orbus Therapeutics

NCT05879367

RECRUITING Phase 1 33 participants

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Northwell Health

NCT02861898

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 1 11 participants

Sonodynamic Therapy in Patients With Recurrent GBM

Shayan Moosa, MD

NCT06039709

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

ACTIVE NOT RECRUITING Phase 3 560 participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

CarThera

NCT05902169

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 1 63 participants

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Patrick Wen, MD

NCT04606316

ACTIVE NOT RECRUITING Phase 1 57 participants

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Northwestern University

NCT04528680

ACTIVE NOT RECRUITING Early Phase 1 42 participants

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

Nader Sanai

NCT05076513

ACTIVE NOT RECRUITING Phase 2 30 participants

Niraparib/TTFields in GBM

Abramson Cancer Center at Penn Medicine

NCT04221503

ACTIVE NOT RECRUITING Phase 1 21 participants

Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma

Jethro Hu

NCT03451799

ACTIVE NOT RECRUITING NA 12 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Northwell Health

NCT03630289

COMPLETED Phase 1 59 participants

Safety and Efficacy of Trans Sodium Crocetinate (TSC) With Radiation and Temozolomide in Newly Diagnosed Glioblastoma

Diffusion Pharmaceuticals

NCT01465347

COMPLETED Phase 2 58 participants

PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma

Massachusetts General Hospital

NCT01112527

COMPLETED Phase 1 15 participants

Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA

Northwell Health

NCT01238237

COMPLETED Phase 1 13 participants

Avelumab With Laser Interstitial Therapy for Recurrent Glioblastoma

Icahn School of Medicine at Mount Sinai

NCT03341806

COMPLETED Phase 2 9 participants

GW572016 to Treat Recurrent Malignant Brain Tumors

National Cancer Institute (NCI)

NCT00107003

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 5
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the GBM Trial Landscape

25 indexed GBM studies · 12 recruiting (48%).

Phase mix: 3 late (III/IV) vs 18 early (I/II).

Top sponsor: Northwell Health (6 trials), 9 others listed. 25 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for GBM?

PlainTrial tracks 25 US clinical trials for GBM, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for GBM?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.