Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Frailty: early-phase trial registry
21 of 49 indexed Frailty trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #281 of 28,707 conditions by registered trial count.
49 US clinical trials · 21 currently recruiting · #281 of 28,707 conditions by registered trial count
Frailty: 49 US clinical trials tracked, 21 recruiting.
Frailty is the subject of 49 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of North Carolina, Chapel Hill, running 3 of these trials.
Enrollment posture brief
Registry condition frailty
OPEN 21 | RECR 43% | LATE 1 | EARLY 12 | RANK #281 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Myelogenous Leukemia (AML) (43% recruiting · 7 trials)
Frailty lists 21 open slots (43% of 49 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Frailty on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Frailty is recruiting above its size-band peers.
21 of 49 indexed trials (42.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Frailty trials is spread across many organizations.
University of North Carolina, Chapel Hill accounts for 3 of 49 trials (6.1%). 38 distinct sponsors appear on at least one study for this condition label.
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Typical Frailty enrolment sits around 66 participants.
Median target enrolment is 66 among the 49 trials that report a genuine target (sentinel values excluded). 28 of those (57.1%) plan for fewer than 100 participants.
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Frailty research is mostly interventional.
40 interventional and 9 observational studies make up this index (81.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
49 total, page 1 of 1
A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings
VA Office of Research and Development
NCT06404970
Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients
The Cleveland Clinic
NCT05725928
Occupational Therapy and Registered Dietitian Services to Reduce Fall Risk Among Home Delivered Meal Clients
Ohio State University
NCT06586970
Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
University of California, Los Angeles
NCT04717869
Evaluation of the Walk With Ease Program for Fall Prevention
Iowa State University
NCT05693025
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
VA Office of Research and Development
NCT05625204
Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.
University of Illinois at Chicago
NCT06374537
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
International Consortium of Circulatory Assist Clinicians
NCT06039176
Reducing Frailty for Older Cancer Survivors Using Supplements II
University of Rochester
NCT06068543
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV
Massachusetts General Hospital
NCT06554717
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
University of North Carolina, Chapel Hill
NCT06988176
Meal Delivery and Exercise
The University of Texas Health Science Center, Houston
NCT04906759
Get Fit for Function
University of Chicago
NCT06359652
SCM Muscle as a Marker for Frailty in Patients Undergoing ENT Surgery
Icahn School of Medicine at Mount Sinai
NCT06704256
Improving Physical Ability and Cellular Senescence Elimination in HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07144293
The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults
UConn Health
NCT06027554
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
Scott Silveira
NCT07144527
Auricular Acupressure in Prehabilitation
University of Chicago
NCT06516198
Precision Medicine and Physical Function
University of North Carolina, Chapel Hill
NCT05877846
Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
Omar Mahmoud
NCT06309225
Prehabilitation for Kidney Transplant Candidates
The Methodist Hospital Research Institute
NCT06886256
PAtient-centered mUltidiSciplinary Care for vEterans Undergoing Surgery (PAUSE)
VA Office of Research and Development
NCT05037292
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
Anne Murray
NCT07224347
Voice-Activated Technology to Improve Mobility in Multimorbid, Frail, Homebound Older Adults (EngAGE)
University of Chicago
NCT05337514
An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer
St. Jude Children's Research Hospital
NCT04733534
The Sedentary to Active Rising to Thrive (START) Trial
Johns Hopkins Bloomberg School of Public Health
NCT06023680
Home Exercise And Resiliency Training (Heart) Club
University of Michigan
NCT05543733
Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
University of Wisconsin, Madison
NCT06184919
Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
University of Pittsburgh
NCT06576297
WE BEAT - HEART Club Fontan Wellness Project: A Virtual Resilience Promotion and Frailty Prevention Program
University of Michigan
NCT05199857
Towards Understanding Between ADT Treatment, Circadian Rhythm, and Physiological Responsiveness
University of Maryland, Baltimore
NCT05968144
Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study
Anne B. Newman
NCT05727384
Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension
University of Pennsylvania
NCT06543745
Remote Exercise Video Adaptations to Maximize Physical Activity in Childhood Cancer
St. Jude Children's Research Hospital
NCT06411704
Measure of Frailty in Perioperative Setting
The Cleveland Clinic
NCT02838511
The Effect of Walking on Frailty
Northwestern University
NCT03654807
HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
National Institute on Aging (NIA)
NCT00183040
Effects of DHEA/Exercise on Bone, Muscle and Balance
National Aeronautics and Space Administration (NASA)
NCT00664053
Post-ICU Palliative Care Intervention (PIPCI) Trial
Columbia University
NCT03456323
Effects of Tai Chi on Frailty in Elderly Adults
Hebrew SeniorLife
NCT01126723
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
Gladwin, Mark, MD
NCT04405180
Synergizing Home Health Rehabilitation Therapy
University of Florida
NCT05411393
Sleep Health Enhancement in Older Adults to Address Frailty
University of Kansas Medical Center
NCT05968820
Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty
TNF Pharmaceuticals
NCT05283486
Supporting Habit Formation to Attenuate Prefrailty in Elders: Pilot Study
Wayne State University
NCT04140890
Pilot Mobile for Dementia and Frailty
University of Washington
NCT05827094
Understanding Changes in Physical Function Using Principles of Precision Medicine
University of North Carolina, Chapel Hill
NCT05581082
Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis
University of Kansas Medical Center
NCT06042244
Mobile Health Intervention to Support Healthful Diet
University of Washington
NCT05236712
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 9 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Frailty records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Frailty trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Frailty page
49 registered trials, 21 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 21 Frailty trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of North Carolina, Chapel Hill sponsors the most Frailty trials on record, review their full trial history before evaluating a specific study. See University of North Carolina, Chapel Hill's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Frailty condition card totals 49 registered trials; most-linked intervention Usual Care; top US site state Illinois. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.