Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Fragile X Syndrome: early-phase trial registry
7 of 17 indexed Fragile X Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,004 of 28,707 conditions by registered trial count.
17 US clinical trials · 7 currently recruiting · #1,004 of 28,707 conditions by registered trial count
Fragile X Syndrome: 17 US clinical trials tracked, 7 recruiting.
Fragile X Syndrome is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Children's Hospital Medical Center, Cincinnati, running 7 of these trials.
Enrollment posture brief
Registry condition fragile-x-syndrome
OPEN 7 | RECR 41% | LATE 2 | EARLY 7 | RANK #1004 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Fragile X Syndrome lists 7 open slots (41% of 17 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Fragile X Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Fragile X Syndrome is recruiting below its size-band peers.
7 of 17 indexed trials (41.2%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Fragile X Syndrome research.
Children's Hospital Medical Center, Cincinnati accounts for 7 of 17 trials (41.2%). 11 distinct sponsors appear on at least one study for this condition label.
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Most Fragile X Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 60 among the 17 trials that report a genuine target (sentinel values excluded). 13 of those (76.5%) plan for fewer than 100 participants.
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Fragile X Syndrome research is mostly interventional.
16 interventional and 1 observational studies make up this index (94.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
17 total, page 1 of 1
Physical Activity and Community EmPOWERment Project
University of North Carolina, Chapel Hill
NCT06740162
Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders
Children's Hospital Medical Center, Cincinnati
NCT06227780
Web Intervention for Parents of Youth With Genetic Syndromes (WINGS)
Rush University Medical Center
NCT06139172
Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age
Children's Hospital Medical Center, Cincinnati
NCT05957549
Speech-in-noise Perception in Autism and Fragile X
Children's Hospital Medical Center, Cincinnati
NCT06088589
Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)
Mirum Pharmaceuticals
NCT07209462
Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG- Infant
Children's Hospital Medical Center, Cincinnati
NCT06560242
An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome
Tetra Discovery Partners
NCT05367960
Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge
Children's Hospital Medical Center, Cincinnati
NCT05418049
Efficacy and Safety Study of STX209 (Arbaclofen) for Social Withdrawal in Adolescents and Adults With Fragile X Syndrome
Seaside Therapeutics
NCT01282268
Pediatric Patients With Metabolic or Other Genetic Disorders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT02769949
Trial of Minocycline to Treat Children With Fragile X Syndrome
University of California, Davis
NCT01053156
Neurophysiological and Acute Pharmacological Studies in FXS Patients
Children's Hospital Medical Center, Cincinnati
NCT02998151
Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)
Novartis Pharmaceuticals
NCT01482143
An Initial Study of AZD7325 in Adults With Fragile X Syndrome
Children's Hospital Medical Center, Cincinnati
NCT03140813
ERG/5-HTP in Fragile X Syndrome (FXS)
Elizabeth Berry-Kravis
NCT05030129
Acamprosate in Youth With Fragile X Syndrome
Indiana University
NCT01300923
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 4 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Fragile X Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Fragile X Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Fragile X Syndrome page
17 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 7 Fragile X Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Children's Hospital Medical Center, Cincinnati sponsors the most Fragile X Syndrome trials on record, review their full trial history before evaluating a specific study. See Children's Hospital Medical Center, Cincinnati's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Fragile X Syndrome condition card totals 17 registered trials; most-linked intervention Placebo; top US site state Ohio. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.