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NCT05209386 · ClinicalTrials.gov registry record · NA
Flexible Representation of Speech
A NA study of Epilepsy, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT05209386: Completed NA study of Epilepsy, sponsored by University of Pittsburgh.
NCT05209386 is a NA study of Epilepsy that has completed, run by University of Pittsburgh. The registered enrollment target is 48 participants, below the 952-participant average among 160 other Epilepsy trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05209386, a NA study of Epilepsy, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratemporal plane, comprised of Heschl's gyrus, the planum polare, and the planum temporale, is capable of the rapid spectrotemporal analysis required to map acoustic information to linguistic representation. Neural activity in this area, however, is rarely studied directly because it is difficult to access with non-invasive measures like scalp electroencephalography (EEG). Capitalizing on the unique opportunity to access these areas via routine clinical stereoelectroencephalography (sEEG) in a patient population, this study seeks to understand how cortical responses reflect the diagnosticity of two acoustic-phonetic dimensions of interest and how responses rapidly and flexibly adapt to changes in listening demands. Examining how neural response to voice onset time (VOT) and fundamental frequency (F0) modulates as a function of perceptual weight carried in signaling phoneme categories, and identifying how changes in listening context shift perceptual weight, will provide invaluable data that indicates how speech processing flexibly adapts to short-term acoustic patterns.
Primary Outcome
Neural activity will be measured via simultaneous EEG-sEEG monitoring in the supratemporal plane as indicated by high-gamma band activity in the electrical signal. Neural activity will be measured as participants listen to acoustic stimuli with gradually manipulated acoustic dimensions, fundamental frequency (F0) and voice onset time (VOT). The data reported here is the number of temporal lobe channels demonstrating significant encoding of change in acoustic dimension (F0 as VOT is held constant
Conditions Studied
Interventions
- BEHAVIORAL Dimension-Based Statistical Learning
Study Locations (1)
Pennsylvania
- UPMC Children's Hospital of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2022-05-02 |
| Est. Completion | 2025-04-10 |
| Phase | NA |
What the finished NCT05209386 record still lists
NCT05209386 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 952-participant average among 160 other Epilepsy trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Epilepsy appearing as the primary indexed condition, and to 1 intervention - of which Dimension-Based Statistical Learning is the first listed.
NCT05209386 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05209386 about?
NCT05209386 is a clinical study titled "Flexible Representation of Speech". The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the aud...
What is the current status of trial NCT05209386?
This trial is currently completed. It is a NA study. The enrollment target is 48 participants. The study started on 2022-05-02. Estimated completion is 2025-04-10.
What conditions does trial NCT05209386 study?
This clinical trial studies the following conditions: Epilepsy.
What interventions are being tested in trial NCT05209386?
The interventions under investigation include: Dimension-Based Statistical Learning (BEHAVIORAL).
Who is sponsoring clinical trial NCT05209386?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05209386 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05209386's enrollment target sits among peer trials
48 89th of 160 higher than 72 of 160 other Epilepsy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Epilepsy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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