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ClinicalTrials.gov 78 recruiting now official registry

Epilepsy clinical trials

78 of 164 indexed Epilepsy trials are currently recruiting.

164 US clinical trials · 78 currently recruiting

Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.

The research picture

Epilepsy has 164 registered US clinical trials, 78 of them open to new participants right now, about 48% of the total.

78
recruiting participants now
48%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
9
top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Phase 123Phase 216Phase 314Phase 47

Active & Recent Trials

164 total, page 4 of 4

COMPLETED 17 participants

In Vivo Imaging of Therapeutic Electric Current Flow

University of Florida

NCT02453763

COMPLETED Phase 1 14 participants

Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients With Medically Refractory Partial Epilepsy

Mayo Clinic

NCT01703143

COMPLETED Phase 1 12 participants

Treatment Development of Triheptanoin (G1D)

Juan Pascual

NCT03041363

COMPLETED Phase 2 11 participants

Efficacy of YKP3089 in Patients With Photosensitive Epilepsy

SK Life Science

NCT00616148

COMPLETED 11 participants

Seizure Detection and Warning System in Epilepsy Patients

Brain Sentinel

NCT02555410

COMPLETED Phase 1 8 participants

Effect of Haemodialysis on the Pharmacokinetics of Ezogabine/Retigabine and Its N-acetyl Metabolite

GlaxoSmithKline

NCT01480609

COMPLETED Phase 2 7 participants

CX-8998 for Absence Seizures

Jazz Pharmaceuticals

NCT03406702

COMPLETED Phase 4 6 participants

Levetiracetam for Benign Rolandic Epilepsy

Johns Hopkins University

NCT00181116

COMPLETED NA 5 participants

Electroencephalography (EEG) and Deep Brain Stimulation (DBS) in Epilepsy

Weill Medical College of Cornell University

NCT00194870

COMPLETED NA 2 participants

Presurgical Motor Mapping With Transcranial Magnetic Stimulation (TMS)

NYU Langone Health

NCT02741193

COMPLETED Phase 1 1 participants

High Definition Cathodal Transcranial Direct Current Stimulation for Treatment of Refractory Partial Onset Epilepsy

NYU Langone Health

NCT02264652

COMPLETED

Pediatric Epilepsy Database

University of Alabama at Birmingham

NCT00204360

COMPLETED Phase 4

Double-Blind, Placebo-Controlled Trial of Vitamin E as Add-on Therapy for Children With Epilepsy

National Center for Research Resources (NCRR)

NCT00004637

COMPLETED Phase 2

E2007 Given as Adjunctive Therapy in Patients With Refractory Partial Seizures

Eisai

NCT00144690

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Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 16
Phase 3 14
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Epilepsy Trial Landscape

164 indexed Epilepsy studies · 78 recruiting (48%).

Phase mix: 21 late (III/IV) vs 39 early (I/II).

Top sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (9 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Epilepsy?

PlainTrial tracks 164 US clinical trials for Epilepsy, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Epilepsy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.