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Diabetic Retinopathy clinical trials
15 of 58 indexed Diabetic Retinopathy trials are currently recruiting.
58 US clinical trials · 15 currently recruiting
Diabetic Retinopathy is the subject of 58 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 4 of these trials.
The research picture
Diabetic Retinopathy has 58 registered US clinical trials, 15 of them open to new participants right now, about 26% of the total.
- 15
- recruiting participants now
- 26%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 4
- top sponsor: National Eye Institute (NEI)
Active & Recent Trials
58 total, page 1 of 2
Village-Integrated Eye Worker Trial II
University of California, San Francisco
NCT03752840
Clinical Applications of Advanced Ophthalmic Imaging
University of Miami
NCT03135327
Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities
University of Wisconsin, Madison
NCT06257082
Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
Johns Hopkins University
NCT04505618
Pivotal Trial of Automated Artificial Intelligence (AI) Based System for Early Diagnosis of Diabetic Retinopathy
iHealthScreen
NCT07151001
National Eye Institute Biorepository for Retinal Diseases
National Eye Institute (NEI)
NCT01496625
Fenofibrate for Prevention of DR Worsening
Jaeb Center for Health Research
NCT04661358
Intraoperative OCT Guidance of Intraocular Surgery II
Duke University
NCT03713268
Biomarker of Diabetic Retinopathy
Indiana University
NCT05079399
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
Boehringer Ingelheim
NCT06321302
Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
University of Alabama at Birmingham
NCT03403686
A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01
Vantage Biosciences
NCT06770933
Sleep, Diabetic Retinopathy and Melatonin
University of Illinois at Chicago
NCT04547439
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
University of Alabama at Birmingham
NCT03403699
Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
MediBeacon
NCT04008121
Implementation of Teleophthalmology in Urban Health Systems Study
University of Wisconsin, Madison
NCT05773495
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
Columbia University
NCT04271709
Camera Qualification Study
Digital Diagnostics
NCT05808699
Predicting Diabetic Retinopathy From Risk Factor Data and Digital Retinal Images
Charles Drew University of Medicine and Science
NCT03694145
WF and PR OCTA in Diabetic Retinopathy
Oregon Health and Science University
NCT03922932
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Diabetic Retinopathy (DR)
Kodiak Sciences
NCT06270836
A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm
Hoffmann-La Roche
NCT04503551
OCT Biomarkers for Diabetic Retinopathy
Oregon Health and Science University
NCT02330042
INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study
Stephen J. Kim, MD
NCT04505566
Vascular Reparative Mechanism in Diabetes
University of Alabama at Birmingham
NCT02119689
4D-150 in Patients With Diabetic Macular Edema
4D Molecular Therapeutics
NCT05930561
A Study of PER-001 in Participants With Diabetic Retinopathy
Perfuse Therapeutics
NCT06003751
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)
Adverum Biotechnologies
NCT05607810
Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy
University of California, Davis
NCT01736059
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
US Department of Veterans Affairs
NCT00119535
Assessment of EyeArt as an Automated Diabetic Retinopathy Screening Tool
Eyenuk
NCT03112005
Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
Bausch & Lomb Incorporated
NCT00198510
Reduction in the Occurrence of Center-Involved Diabetic Macular Edema
Chromaderm
NCT00090519
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
National Eye Institute (NEI)
NCT00647439
The Comparative Effectiveness of Telemedicine to Detect Diabetic Retinopathy
Legacy Health System
NCT01364129
Pediatric Type 1 Diabetes and Retinopathy
University of Florida
NCT02691312
RETeval Study for Diabetic Retinopathy
Inoveon Corporation
NCT01950663
Anti-VEGF Treatment for Prevention of PDR/DME
Jaeb Center for Health Research
NCT02634333
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
VisionQuest Biomedical
NCT03069729
Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy
Novartis
NCT00130845
PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)
Quark Pharmaceuticals
NCT01445899
Levodopa for Diabetic Retinopathy
Emory University
NCT07444892
A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy
Hoffmann-La Roche
NCT04265261
A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema
Oxurion
NCT04527107
A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin)
Jaeb Center for Health Research
NCT00336323
Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders
National Eye Institute (NEI)
NCT00101764
Comparing Visual Acuity Measurements (How Well You Can See) Using a Standard ETDRS Chart & a Handheld ETDRS Chart
Julia Haller
NCT01622816
Comparing 3 Imaging Systems
University of Wisconsin, Madison
NCT05022615
Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema
Rocky Mountain Retina Consultants
NCT00387582
A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers
TargeGen
NCT00414999
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 13 |
| Phase 3 | 7 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetic Retinopathy Trial Landscape
58 indexed Diabetic Retinopathy studies · 15 recruiting (26%).
Phase mix: 8 late (III/IV) vs 21 early (I/II).
Top sponsor: National Eye Institute (NEI) (4 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetic Retinopathy?
PlainTrial tracks 58 US clinical trials for Diabetic Retinopathy, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetic Retinopathy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.