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NCT03403699 · ClinicalTrials.gov registry record
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
A clinical trial of Diabetic Retinopathy and Diabetes Complications, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- 20
- Enrollment target
- 1
- Study location
NCT03403699: Recruiting study of Diabetic Retinopathy and Diabetes Complications, sponsored by University of Alabama at Birmingham.
NCT03403699 is a study of Diabetic Retinopathy and Diabetes Complications that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 20 participants, below the 1,676-participant average among 57 other Diabetic Retinopathy trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03403699, a study of Diabetic Retinopathy and Diabetes Complications, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This study proposes to carefully examine the hypothesis that human inducible pluripotent stem cells (iPSCs) can be effectively employed as a future therapeutic option for individuals with diabetic retinopathy and macular ischemia. iPSCs will be generated from the peripheral blood cells of subjects with diabetes and age matched controls. The human iPSC cells will be used to generate mesoderm cells for injection into the vitreous cavity of diabetic rodents and primate eyes. The ability of mesoderm cells to generate endothelial cells and pericytes in areas of degenerated capillaries will be examined. The human iPSCs will also be used to generate hematopoietic CD34+CD45+ cells. The combination of CD34+CD45+ cells derived from iPSCs and iPSC derived mesoderm will be examined in combination for their potentially beneficial effect to enhance the vessel formation.
Primary Outcome
Blood will be collected from the patient and cells will be isolated and shipped to ALSTEM for generation of iPSCs
Conditions Studied
Interventions
- BIOLOGICAL Generation of inducible pluripotent stem cells
Study Locations (1)
Alabama
- University of Alabama at Birmingham - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2018-01-11 |
| Est. Completion | 2027-12-31 |
What NCT03403699 shows while recruiting
NCT03403699 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,676-participant average among 57 other Diabetic Retinopathy trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Diabetic Retinopathy appearing as the primary indexed condition, and to 1 intervention - of which Generation of inducible pluripotent stem cells is the first listed.
NCT03403699 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT03403699 about?
NCT03403699 is a clinical study titled "Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy". This study proposes to carefully examine the hypothesis that human inducible pluripotent stem cells (iPSCs) can be effectively employed as a future therapeutic option for individuals with diabetic retinopathy and macular ischemia. iPSCs will be generated from the peripheral blood cells of subjects w...
What is the current status of trial NCT03403699?
This trial is currently recruiting. The enrollment target is 20 participants. The study started on 2018-01-11. Estimated completion is 2027-12-31.
What conditions does trial NCT03403699 study?
This clinical trial studies the following conditions: Diabetic Retinopathy, Diabetes Complications.
What interventions are being tested in trial NCT03403699?
The interventions under investigation include: Generation of inducible pluripotent stem cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT03403699?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03403699 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03403699's enrollment target sits among peer trials
20 50th of 57 higher than 7 of 57 other Diabetic Retinopathy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetic Retinopathy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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