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ClinicalTrials.gov 49 recruiting now official registry

Diabetes Mellitus clinical trials

49 of 210 indexed Diabetes Mellitus trials are currently recruiting.

210 US clinical trials · 49 currently recruiting

Diabetes Mellitus is the subject of 210 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 8 of these trials.

The research picture

Diabetes Mellitus has 210 registered US clinical trials, 49 of them open to new participants right now, about 23% of the total.

49
recruiting participants now
23%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
8
top sponsor: Takeda
Phase 113Phase 219Phase 318Phase 48

Active & Recent Trials

210 total, page 4 of 5

COMPLETED NA 86 participants

Community Paramedicine Program to Improve Diabetes Care Quality, Equity, and Outcomes

Mayo Clinic

NCT04385758

COMPLETED NA 86 participants

A Clinical Study of the C8 MediSensors Optical Glucose Monitor™

C8 MediSensors

NCT01726114

COMPLETED NA 85 participants

A Quality Improvement Process to Support Delivery of Cardiovascular Care in Community Mental Health Organizations

Johns Hopkins University

NCT04696653

COMPLETED 85 participants

FreeStyle Libre Continuous Glucose Monitoring System Accuracy Study

Abbott Diabetes Care

NCT04464772

COMPLETED NA 85 participants

Assessing Non-adjunctive CGM Safety at Home and in New Markets

DexCom

NCT04585139

COMPLETED Phase 1 84 participants

Single-Dose And Multiple-Dose Safety And Tolerability Study Of PF-04856883 In Type 2 Diabetic Adult Females

Pfizer

NCT01301456

COMPLETED NA 74 participants

Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.

VA Office of Research and Development

NCT01574157

COMPLETED Phase 2 72 participants

Safety, Tolerability, Pharmacokinetics,Pharmacodynamics Study of LAPS-Exendin in Subjects of Type 2 Diabetes Mellitus

Hanmi Pharmaceutical Company Limited

NCT01452451

COMPLETED NA 72 participants

Prediction of CK-MB Release During Otherwise Successful Stenting Procedure

Icahn School of Medicine at Mount Sinai

NCT00489242

COMPLETED 70 participants

Incidence and Predictors of Acute and Chronic Complications in Patients With Diabetes and Severe COVID-19

University of Michigan

NCT05200819

COMPLETED NA 70 participants

Assessing the Risk of Developing Type II Diabetes Using Serum Biomarkers in Patients Diagnosed With Obstructive Sleep Apnea

Mike O'Callaghan Military Hospital

NCT01447251

COMPLETED NA 69 participants

A Mobile Phone-based Program for Adults With Prediabetes

University of Michigan

NCT03025607

COMPLETED NA 67 participants

Adapting and Assessing the Feasibility of a Diabetes Self-management Telehealth Intervention

University of Utah

NCT04600622

COMPLETED NA 63 participants

Comorbidities And Reducing inEquitieS

Medstar Health Research Institute

NCT04836221

COMPLETED NA 61 participants

Mobile Insulin Titration Intervention

NYU Langone Health

NCT01879579

COMPLETED NA 60 participants

Evaluation of a Patient Portal Intervention to Address Diabetes Care Gaps

Vanderbilt University Medical Center

NCT04728620

COMPLETED NA 60 participants

Financial Incentives Telephone Education and Skills Trial in African Americans With Diabetes (FITEST)

State University of New York at Buffalo

NCT02722499

COMPLETED 57 participants

Hippocampal Metabolism and Function in Patients With Type 1 Diabetes

University of Minnesota

NCT01852968

COMPLETED NA 53 participants

Diabetes Risk Education and Communication Trial

Northwestern University

NCT03283657

COMPLETED NA 51 participants

Effectiveness and Safety Study of the Dexcom G4 Platinum With Modified Algorithm

DexCom

NCT02087995

COMPLETED NA 50 participants

A New Glucose Meter With Alternative Site Testing

Ascensia Diabetes Care

NCT00797212

COMPLETED NA 50 participants

Effects of Use of a Connected Pillbox On Medication Adherence

University of Pennsylvania

NCT02593032

COMPLETED NA 50 participants

Facilitating Improvements in Kidney Health Using a Smartphone App Counseling Program in Patients With Diabetes

Geisinger Clinic

NCT03015480

COMPLETED 49 participants

Green Digital Diabetes Waste Project

Florida State University

NCT06071325

COMPLETED NA 47 participants

Chronic Care Management/Patient Relationship Management Proof of Concept

Denver Health and Hospital Authority

NCT01182480

COMPLETED NA 44 participants

Diabetic Foot Ulcer (DFU) Rapid Pathogen Identification

University of Michigan

NCT06569238

COMPLETED NA 43 participants

Effect of Weight-Bearing Exercise on People With Diabetes and Neuropathic Feet

Washington University School of Medicine

NCT00763087

COMPLETED Phase 2 40 participants

Dysvascular Amputation Self-Management of Health

University of Colorado, Denver

NCT04083456

COMPLETED Early Phase 1 40 participants

Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation

Northwell Health

NCT04742023

COMPLETED Phase 1 39 participants

First-In-Human Study of GFB-024 in Healthy Overweight and Obese Participants, and Participants With Type 2 Diabetes

Goldfinch Bio

NCT04880291

COMPLETED NA 38 participants

Managing Diabetes Mindfully Study

HealthPartners Institute

NCT01796834

COMPLETED Phase 4 37 participants

The Management of Glucocorticoid-Induced Hyperglycemia in Hospitalized Patients

Baylor College of Medicine

NCT01810952

COMPLETED Phase 2 36 participants

Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells

Emory University

NCT00166036

COMPLETED NA 34 participants

A Mind-Body Intervention for Diabetes Management: A Pilot Study

Dartmouth-Hitchcock Medical Center

NCT04944264

COMPLETED NA 33 participants

Improving Medical Training for the Care of Chronic Conditions

VA Office of Research and Development

NCT00676208

COMPLETED 30 participants

Observational Study to Evaluate the Effectiveness and Safety of the Dexcom G4 Continuous Glucose Monitoring System in Pediatrics

DexCom

NCT02363907

COMPLETED Phase 2 30 participants

Effect of LY333531 on Vascular and Neural Functions

Chromaderm

NCT00482976

COMPLETED NA 30 participants

Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00046267

COMPLETED Phase 1 30 participants

Bioequivalence Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin XR Tablet (Manufactured in Mt Vernon, IN) Relative to 5 mg Saxagliptin Tablet and 500 mg Metformin XR Tablet (Manufactured in Evansville, IN)

AstraZeneca

NCT01192139

COMPLETED NA 27 participants

A Continuous Glucose Monitor Based Insulin Bolus Calculator (CGM-IBC) Study B

Welldoc

NCT05343065

COMPLETED Phase 3 26 participants

Clinical Usability of Nasal Glucagon in Treatment of Hypoglycemia in Children and Adolescents

Eli Lilly and Company

NCT02402933

COMPLETED Phase 1 24 participants

Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes

University of Colorado, Denver

NCT03620773

COMPLETED Phase 2 24 participants

A Study Comparing the Pharmacodynamic Properties of Insulin VIAJECT™, Regular Human Insulin, and Insulin Lispro

Biodel

NCT01000922

COMPLETED 24 participants

Diabetic Ketoacidosis and Its Impact on the Brain

Stanford University

NCT01753934

COMPLETED Phase 4 24 participants

A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus

Emory University

NCT04157738

COMPLETED NA 22 participants

Automated Insulin Delivery for INpatients With DysGlycemia (AIDING) Feasibility

Emory University

NCT04714216

COMPLETED Phase 2 22 participants

Randomized Controlled Trial of Vitamin D3 in Diabetic Kidney Disease

University of Washington

NCT00552409

COMPLETED Phase 1 21 participants

A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome

Washington University School of Medicine

NCT02829268

COMPLETED 20 participants

Effects of URI on Diabetic Subjects Utilizing Technosphere Insulin After a Meal Challenge

Mannkind Corporation

NCT00642681

COMPLETED NA 20 participants

Advancing the Standard of Care for Pin Site Care

Duke University

NCT01965665

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Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 19
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus Trial Landscape

210 indexed Diabetes Mellitus studies · 49 recruiting (23%).

Phase mix: 26 late (III/IV) vs 32 early (I/II).

Top sponsor: Takeda (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus?

PlainTrial tracks 210 US clinical trials for Diabetes Mellitus, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.