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ClinicalTrials.gov 49 recruiting now official registry

Diabetes Mellitus clinical trials

49 of 210 indexed Diabetes Mellitus trials are currently recruiting.

210 US clinical trials · 49 currently recruiting

Diabetes Mellitus is the subject of 210 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 8 of these trials.

The research picture

Diabetes Mellitus has 210 registered US clinical trials, 49 of them open to new participants right now, about 23% of the total.

49
recruiting participants now
23%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
8
top sponsor: Takeda
Phase 113Phase 219Phase 318Phase 48

Active & Recent Trials

210 total, page 3 of 5

COMPLETED Phase 1 500 participants

Potential Risk Factors for Stroke

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001368

COMPLETED NA 479 participants

Unmet Social Needs Study

VA Office of Research and Development

NCT04977583

COMPLETED NA 473 participants

Improving Medication Adherence in the Alabama Black Belt

Weill Medical College of Cornell University

NCT02274844

COMPLETED NA 467 participants

Can Tailored Patient Letters Improve The Quality Of Diabetic Patient Care?

Scranton-Temple Residency Program

NCT00984841

COMPLETED NA 460 participants

Effect of Case-Management Using Home Monitoring on Diabetes and Blood Pressure Outcomes

Minneapolis Veterans Affairs Medical Center

NCT00935441

COMPLETED Phase 3 400 participants

Treatment of Peripheral Neuropathy in Patients With Diabetes

Eli Lilly and Company

NCT00044421

COMPLETED Phase 3 390 participants

Efficacy and Safety Study of Alogliptin and Insulin in the Treatment of Type 2 Diabetes.

Takeda

NCT00286429

COMPLETED Phase 2 386 participants

Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus

Takeda

NCT00760344

COMPLETED NA 354 participants

Initiate and Maintain Physical Activity in Clinics: The IMPACT Diabetes Study

Stanford University

NCT02061579

COMPLETED Phase 4 351 participants

Periprocedural Glycemic Control in Patients Undergoing Coronary Angiography

NYU Langone Health

NCT01419652

COMPLETED NA 320 participants

Hawaii Patient Reward And Incentives to Support Empowerment

University of Hawaii

NCT02123251

COMPLETED Phase 4 305 participants

Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone.

Takeda

NCT00672919

COMPLETED NA 305 participants

MY PALS: A Community-Based Physical Activity Support Program for Older Adults

University of Washington

NCT00132288

COMPLETED NA 302 participants

Effectiveness of Home-Based Health Messaging for Patients With Hypertension and Diabetes

US Department of Veterans Affairs

NCT00119054

COMPLETED Phase 2 300 participants

A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)

National Center for Research Resources (NCRR)

NCT00015626

COMPLETED NA 300 participants

Improving Aspirin Use in Diabetes: A Cluster Randomized Trial

Northwestern University

NCT00262977

COMPLETED Phase 3 299 participants

Safety and Efficacy of Inhaled Insulin in Patients With Diabetes and Asthma or COPD

Eli Lilly and Company

NCT00157339

COMPLETED NA 295 participants

Health Coach Program to Improve Chronic Disease Outcomes Following an Emergency Department Visit

Alameda County Medical Center

NCT02386540

COMPLETED 287 participants

POGO® Automatic Blood Glucose Monitoring System Clinical Study

Intuity Medical

NCT02333864

COMPLETED NA 273 participants

Post Approval Study of the Eversense® Continuous Glucose Monitoring

Senseonics

NCT03908125

COMPLETED Phase 2 270 participants

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

National Heart, Lung, and Blood Institute (NHLBI)

NCT00666172

COMPLETED NA 260 participants

Proactive Diabetes Case Management

US Department of Veterans Affairs

NCT00013208

COMPLETED NA 254 participants

Veterans Walk for Health Study

US Department of Veterans Affairs

NCT00123435

COMPLETED NA 251 participants

Social Risk Score, Clinical Decision Support Tool and Closed Loop Referral for Social Risk Screen and Referral

Johns Hopkins University

NCT05574699

COMPLETED Phase 3 250 participants

Compare Blood Sugar Level Between Lantus in the Morning and Other Insulins in Type 1 Diabetes Adolescents

Sanofi

NCT00046501

COMPLETED NA 250 participants

Pharmacist-led Group Medical Visits to Help With Diabetes Management

VA Office of Research and Development

NCT00554671

COMPLETED NA 244 participants

Health Promoters and Pharmacists in Diabetes Team Management

University of Illinois at Chicago

NCT01498159

COMPLETED 240 participants

Comprehension of Discharge Instructions for Diabetes Therapy and Hospital Readmission

University of Pittsburgh

NCT03279627

COMPLETED Phase 2 236 participants

AMG 151 Amgen Protocol Number 20100761

Amgen

NCT01464437

COMPLETED 215 participants

The Impact of Diabetes on REvascularization

Vanderbilt University Medical Center

NCT03085524

COMPLETED NA 196 participants

CONtrolling Disease Using Inexpensive IT - Hypertension in Diabetes

University of Massachusetts, Worcester

NCT01416766

COMPLETED Phase 3 180 participants

Community Diabetes Education Program Evaluation "Code Evaluation"

The University of Texas Health Science Center, Houston

NCT00151190

COMPLETED Phase 1 174 participants

Self Monitoring of Blood Glucose With Finger Tip vs. Alternate Site Sampling: Effect on Long Term Glycemic Control

Boston Medical Center

NCT00207207

COMPLETED 159 participants

Accuracy and Precision of the True Vie I3 Continuous Glucose Monitoring System: an Open Label, Multi-Center Trial

Sinocare

NCT05806554

COMPLETED NA 155 participants

Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk

Icahn School of Medicine at Mount Sinai

NCT03036254

COMPLETED NA 152 participants

Internet-based Diabetes Education and Case Management

US Department of Veterans Affairs

NCT00105898

COMPLETED 137 participants

Impaired Wound Healing in Diabetic Foot Ulceration

Beth Israel Deaconess Medical Center

NCT00739323

COMPLETED NA 136 participants

Conexion: A Localized Information Resource on Diabetes and Depression for a Low-income Hispanic Community

Columbia University

NCT03984929

COMPLETED Phase 2 135 participants

A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema

Oxurion

NCT04527107

COMPLETED NA 132 participants

Mindful Stress Reduction in Diabetes Self-management Education for Veterans

VA Office of Research and Development

NCT02928952

COMPLETED NA 131 participants

Day and Night Closed-loop in Young People With Type 1 Diabetes

Jaeb Center for Health Research

NCT02925299

COMPLETED NA 117 participants

Interprofessional Training to Improve Diabetes Care: The ReSPECT Trial

US Department of Veterans Affairs

NCT00854594

COMPLETED NA 108 participants

Family PALS (PArtners in Lifestyle Support)

University of North Carolina, Chapel Hill

NCT01324011

COMPLETED Phase 3 108 participants

Diabetes Therapy to Improve BMI and Lung Function in CF

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00072904

COMPLETED NA 102 participants

Evaluation of a New Blood Glucose Meter System With Capillary and Venous Blood

Ascensia Diabetes Care

NCT00797563

COMPLETED NA 100 participants

Comparison of Glycemic Control With Smartphone Application

Icahn School of Medicine at Mount Sinai

NCT05592860

COMPLETED Phase 3 98 participants

Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus

Mayo Clinic

NCT00217061

COMPLETED NA 97 participants

Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions

Treatment Research Institute

NCT02059005

COMPLETED NA 92 participants

T2D Pilot Study for Patients With Uncontrolled Type 2 Diabetes

Duke University

NCT06988540

COMPLETED NA 91 participants

QBSAfe: A Novel Approach to Diabetes Management Focused on Quality of Life, Burden of Treatment, Social Integration and Avoidance of Future Events

Yale University

NCT04514523

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Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 19
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus Trial Landscape

210 indexed Diabetes Mellitus studies · 49 recruiting (23%).

Phase mix: 26 late (III/IV) vs 32 early (I/II).

Top sponsor: Takeda (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus?

PlainTrial tracks 210 US clinical trials for Diabetes Mellitus, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.